N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-7-yl)phenyl)acrylamide

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Chemical Name:N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-7-yl)phenyl)acrylamide
CAS No.:1313036-25-7
Molecular Formula:C₂₇H₂₈N₆O₂S
Molecular Weight:500.624
Hs Code.:

Synonyms:N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-7-yl)phenyl)acrylamide

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Chemical Property of N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-7-yl)phenyl)acrylamide

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Technology Process of N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-7-yl)phenyl)acrylamide

There total 12 articles about N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-7-yl)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.57%

: 1313036-46-2
7-(3-aminophenyl)-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)thieno[3,2-d]pyrimidin-2-amine

: 814-68-6,25189-84-8
acryloyl chloride

: 1313036-25-7
N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-7-yl)phenyl)acrylamide

Guidance literature:: 7-(3-aminophenyl)-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)thieno[3,2-d]pyrimidin-2-amine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.0833333h;

acryloyl chloride; In dichloromethane;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1313036-25-7
N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-7-yl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

3: toluene-4-sulfonic acid / 2,2,2-trifluoroethanol / 0.75 h / 150 °C / Microwave

4: hydrogen / palladium 10% on activated carbon / methanol / 1 h

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 0 °C

With hydrogen; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; 2,2,2-trifluoroethanol; N,N-dimethyl-formamide; 3: Buckwald's amination;

Reference yield:

: 22288-78-4
Methyl 3-aminothiophene-2-carboxylate

: 1313036-25-7
N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-7-yl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 8 steps

1: 2 h / 200 °C / Neat (no solvent)

2: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 2 h / Reflux

3: hydrogen; sodium hydrogencarbonate / palladium 10% on activated carbon / ethyl acetate; ethanol / 5 h

4: bromine; periodic acid / acetonitrile / 2 h / Reflux

5: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; Isopropyl acetate / 16 h / 90 °C

6: toluene-4-sulfonic acid / 2,2,2-trifluoroethanol / 0.75 h / 150 °C / Microwave

7: hydrogen / palladium 10% on activated carbon / methanol / 1 h

8: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 0 °C

With hydrogen; bromine; sodium hydrogencarbonate; sodium carbonate; toluene-4-sulfonic acid; periodic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; 2,2,2-trifluoroethanol; Isopropyl acetate; ethyl acetate; toluene; acetonitrile; 6: Buckwald's amination;