7-(3-aminophenyl)-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)thieno[3,2-d]pyrimidin-2-amine

Base Information

Chemical Name:7-(3-aminophenyl)-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)thieno[3,2-d]pyrimidin-2-amine
CAS No.:1313036-46-2
Molecular Formula:C₂₄H₂₆N₆OS
Molecular Weight:446.576
Hs Code.:

Synonyms:7-(3-aminophenyl)-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)thieno[3,2-d]pyrimidin-2-amine

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Chemical Property of 7-(3-aminophenyl)-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)thieno[3,2-d]pyrimidin-2-amine

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Technology Process of 7-(3-aminophenyl)-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)thieno[3,2-d]pyrimidin-2-amine

There total 11 articles about 7-(3-aminophenyl)-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)thieno[3,2-d]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.61%

: 1313036-45-1
N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-7-(3-nitrophenyl)thieno[3,2-d]pyrimidin-2-amine

: 1313036-46-2
7-(3-aminophenyl)-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)thieno[3,2-d]pyrimidin-2-amine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 1h;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1313036-46-2
7-(3-aminophenyl)-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)thieno[3,2-d]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

3: toluene-4-sulfonic acid / 2,2,2-trifluoroethanol / 0.75 h / 150 °C / Microwave

4: hydrogen / palladium 10% on activated carbon / methanol / 1 h

With hydrogen; potassium carbonate; toluene-4-sulfonic acid; palladium 10% on activated carbon; In methanol; ethanol; 2,2,2-trifluoroethanol; N,N-dimethyl-formamide; 3: Buckwald's amination;

Reference yield:

: 22288-78-4
Methyl 3-aminothiophene-2-carboxylate

: 1313036-46-2
7-(3-aminophenyl)-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)thieno[3,2-d]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 7 steps

1: 2 h / 200 °C / Neat (no solvent)

2: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 2 h / Reflux

3: hydrogen; sodium hydrogencarbonate / palladium 10% on activated carbon / ethyl acetate; ethanol / 5 h

4: bromine; periodic acid / acetonitrile / 2 h / Reflux

5: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; Isopropyl acetate / 16 h / 90 °C

6: toluene-4-sulfonic acid / 2,2,2-trifluoroethanol / 0.75 h / 150 °C / Microwave

7: hydrogen / palladium 10% on activated carbon / methanol / 1 h

With hydrogen; bromine; sodium hydrogencarbonate; sodium carbonate; toluene-4-sulfonic acid; periodic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; ethanol; 2,2,2-trifluoroethanol; Isopropyl acetate; ethyl acetate; toluene; acetonitrile; 6: Buckwald's amination;