2-[(Ethoxycarbonyl)amino]-3-phenylpropanoic acid

Base Information

Chemical Name:2-[(Ethoxycarbonyl)amino]-3-phenylpropanoic acid
CAS No.:81375-37-3
Molecular Formula:C₁₂H₁₅NO₄
Molecular Weight:237.255
Hs Code.:
Nikkaji Number:J1.008.183A
NSC Number:76270

Synonyms:2-[(ethoxycarbonyl)amino]-3-phenylpropanoic acid;81375-37-3;2-(ethoxycarbonylamino)-3-phenylpropanoic acid;SCHEMBL996293;NSC76270;STR05003;NSC-76270;AKOS000154907;AKOS017269907;EN300-221618;2-[(ethoxycarbonyl)amino]-3-phenylpropanoicacid;Z64432592

Suppliers and Price of 2-[(Ethoxycarbonyl)amino]-3-phenylpropanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2-[(Ethoxycarbonyl)amino]-3-phenylpropanoic acid

Chemical Property:

Melting Point:76 °C
Boiling Point:419.0±38.0 °C(Predicted)
Density:1.213±0.06 g/cm3(Predicted)
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:237.10010796
Heavy Atom Count:17
Complexity:261

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)NC(CC1=CC=CC=C1)C(=O)O

Technology Process of 2-[(Ethoxycarbonyl)amino]-3-phenylpropanoic acid

There total 3 articles about 2-[(Ethoxycarbonyl)amino]-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 150-30-1,25191-15-5,658-69-5,67675-33-6
Phenylalanine

: 541-41-3
chloroformic acid ethyl ester

: 81375-37-3
N-(ethoxycarbonyl)phenylalanine

Guidance literature:: With sodium carbonate; sodium hydroxide; for 1.5h;
DOI:10.1021/acs.joc.1c01546

Reference yield:

: 3235-26-5
2-(N-acetylamino)-2-benzylpropanedioic diethyl ester

: 81375-37-3
N-(ethoxycarbonyl)phenylalanine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water / 110 °C / Microwave irradiation

2: sodium hydroxide / 1,4-dioxane / 60 °C

With hydrogenchloride; sodium hydroxide; In 1,4-dioxane; water;
DOI:10.1021/acs.orglett.8b02791