Ethyl 2'-methyl[2,4'-bithiazole]-4-carboxylate

Base Information

Chemical Name:Ethyl 2'-methyl[2,4'-bithiazole]-4-carboxylate
CAS No.:174223-30-4
Molecular Formula:C₁₀H₁₀N₂O₂S₂
Molecular Weight:254.334
Hs Code.:
DSSTox Substance ID:DTXSID801248314
Nikkaji Number:J2.755.214E

Synonyms:Maybridge3_007042;DTXSID801248314;HMS1451A02;CCG-46530;IDI1_018429;Ethyl 2'-methyl[2,4'-bithiazole]-4-carboxylate;SR-01000636221-1;BRD-K68013979-001-01-2;2'-Methyl-2,4'-bithiazole-4-carboxylic acid ethyl ester;174223-30-4

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Chemical Property of Ethyl 2'-methyl[2,4'-bithiazole]-4-carboxylate

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:254.01836991
Heavy Atom Count:16
Complexity:265

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=CSC(=N1)C2=CSC(=N2)C

Technology Process of Ethyl 2'-methyl[2,4'-bithiazole]-4-carboxylate

There total 1 articles about Ethyl 2'-methyl[2,4'-bithiazole]-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6436-59-5
ethyl 2-methylthiazole-4-carboxylate

: 174223-30-4
ethyl 2'-methyl-2,4'-bithiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium hydroxide / water / 2 h / 70 °C

2: Lawessons reagent / toluene / 2 h / Reflux

3: ethanol / 2 h / Reflux

With Lawessons reagent; ammonium hydroxide; In ethanol; water; toluene;
DOI:10.1021/ja110166x

Reference yield:

: 174223-30-4
ethyl 2'-methyl-2,4'-bithiazole-4-carboxylate

: C₃₇H₃₇N₃O₃S₃

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide; water / ethanol / 12 h / 0 - 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 8 h / 110 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ml400470s

Reference yield:

: 174223-30-4
ethyl 2'-methyl-2,4'-bithiazole-4-carboxylate

: 59979-01-0
thiocillin I

Guidance literature:: Multi-step reaction with 18 steps

1.1: selenium(IV) oxide / acetic acid / 12 h / Reflux

2.1: tetrahydrofuran / 0.5 h / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

4.1: ammonium acetate / 12 h / Reflux

5.1: potassium carbonate / ethanol; dichloromethane

6.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C

7.1: lithium hydroxide / tetrahydrofuran; water / 2 h

8.1: dmap; triethylamine / dichloromethane / 3 h / Inert atmosphere

9.1: BOP-Cl; triethylamine / acetonitrile / 3 h

10.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

11.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1 h / Inert atmosphere

12.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h

13.1: Dess-Martin periodane / dichloromethane / 2 h

14.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water / 2 h

14.2: pH 2

15.1: BOP-Cl; triethylamine / acetonitrile / Inert atmosphere

16.1: lithium hydroxide / tetrahydrofuran; water / 2 h / 20 °C

16.2: pH 3

17.1: dichloromethane / 2 h / 20 °C

18.1: diphenyl phosphoryl azide / N,N-dimethyl-formamide / 2 h / 20 °C

With 1H-imidazole; dmap; selenium(IV) oxide; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; diphenyl phosphoryl azide; BOP-Cl; ammonium acetate; tetrabutyl ammonium fluoride; potassium carbonate; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetonitrile; 4.1: Bohlmann-Rahtz reaction;
DOI:10.1021/ja110166x