5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2-({1-[3-(trifluoromethyl)benzyl]-1H-1,2,3-triazol-4-yl}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Base Information

Chemical Name:5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2-({1-[3-(trifluoromethyl)benzyl]-1H-1,2,3-triazol-4-yl}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
CAS No.:1332502-18-7
Molecular Formula:C₂₂H₁₇ClF₆N₆O₂
Molecular Weight:546.859
Hs Code.:

Synonyms:5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2-({1-[3-(trifluoromethyl)benzyl]-1H-1,2,3-triazol-4-yl}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

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Chemical Property of 5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2-({1-[3-(trifluoromethyl)benzyl]-1H-1,2,3-triazol-4-yl}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

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Technology Process of 5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2-({1-[3-(trifluoromethyl)benzyl]-1H-1,2,3-triazol-4-yl}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

There total 6 articles about 5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2-({1-[3-(trifluoromethyl)benzyl]-1H-1,2,3-triazol-4-yl}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1332502-73-4
5-(4-chlorophenyl)-2-(prop-2-yn-1-yl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

: 402-23-3
1-bromomethyl-3-trifluoromethylbenzene

: 1332502-18-7
5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2-({1-[3-(trifluoromethyl)benzyl]-1H-1,2,3-triazol-4-yl}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: 1-bromomethyl-3-trifluoromethylbenzene; With sodium azide; In acetonitrile; at 20 ℃; for 1h;

5-(4-chlorophenyl)-2-(prop-2-yn-1-yl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one; With copper(II) acetate monohydrate; In acetonitrile; at 20 ℃; for 264h;

Reference yield:

: 536-40-3
4-chlorobenzoic acid hydrazide

: 1332502-18-7
5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2-({1-[3-(trifluoromethyl)benzyl]-1H-1,2,3-triazol-4-yl}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 50 °C

2.1: sodium hydroxide; water / Reflux

2.2: 20 °C / pH 1

3.1: pyridine / 0.5 h / 35 °C / Inert atmosphere

3.2: 70 °C

4.1: sodium tetrahydroborate; methanol / 1.5 h / Cooling with ice

5.1: potassium carbonate / acetonitrile / 1 h / Reflux

6.1: sodium azide / acetonitrile / 1 h / 20 °C

6.2: 264 h / 20 °C

With pyridine; methanol; sodium tetrahydroborate; sodium azide; water; potassium carbonate; sodium hydroxide; In tetrahydrofuran; acetonitrile;

Reference yield:

: 1228650-21-2
ethyl N-({2-[(4-chlorophenyl)carbonyl]hydrazinyl}carbonyl)glycinate

: 1332502-18-7
5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2-({1-[3-(trifluoromethyl)benzyl]-1H-1,2,3-triazol-4-yl}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / Reflux

1.2: 20 °C / pH 1

2.1: pyridine / 0.5 h / 35 °C / Inert atmosphere

2.2: 70 °C

3.1: sodium tetrahydroborate; methanol / 1.5 h / Cooling with ice

4.1: potassium carbonate / acetonitrile / 1 h / Reflux

5.1: sodium azide / acetonitrile / 1 h / 20 °C

5.2: 264 h / 20 °C

With pyridine; methanol; sodium tetrahydroborate; sodium azide; water; potassium carbonate; sodium hydroxide; In acetonitrile;