5-Chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-{[3-pyridazin-4-yl-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Base Information

Chemical Name:5-Chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-{[3-pyridazin-4-yl-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide
CAS No.:1354786-69-8
Molecular Formula:C₃₄H₂₄ClF₄N₅O₅S₂
Molecular Weight:758.174
Hs Code.:

Synonyms:5-Chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-{[3-pyridazin-4-yl-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

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Chemical Property of 5-Chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-{[3-pyridazin-4-yl-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

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Technology Process of 5-Chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-{[3-pyridazin-4-yl-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

There total 7 articles about 5-Chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-{[3-pyridazin-4-yl-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1354786-55-2
3-pyridazin-4-yl-3'-(trifluoromethyl)biphenyl-4-ol

: 1235406-57-1
5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

: 1354786-69-8
5-Chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-{[3-pyridazin-4-yl-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 18h;

Reference yield:

: 191724-12-6
3'-(trifluoromethyl)[1,1'-biphenyl]-4-ol

: 1354786-69-8
5-Chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-{[3-pyridazin-4-yl-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; N-iodo-succinimide / 0 - 20 °C

2: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 45 °C / Inert atmosphere

3: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C

With N-iodo-succinimide; potassium carbonate; acetic acid; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dimethyl sulfoxide; N,N-dimethyl-formamide; 2: Stille Coupling;

Reference yield:

: 540-38-5
p-Iodophenol

: 1354786-69-8
5-Chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-{[3-pyridazin-4-yl-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere

2: acetic acid; N-iodo-succinimide / 0 - 20 °C

3: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 45 °C / Inert atmosphere

4: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C

With N-iodo-succinimide; sodium hydrogencarbonate; potassium carbonate; acetic acid; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Suzuki Coupling / 3: Stille Coupling;