2-[(5-chloro-1-hydroxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:2-[(5-chloro-1-hydroxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid 9H-fluoren-9-ylmethyl ester
CAS No.:887476-49-5
Molecular Formula:C₂₈H₂₃ClN₂O₄
Molecular Weight:486.955
Hs Code.:

2-[(5-chloro-1-hydroxy-1<i>H</i>-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid 9<i>H</i>-fluoren-9-ylmethyl ester

Synonyms:2-[(5-chloro-1-hydroxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of 2-[(5-chloro-1-hydroxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of 2-[(5-chloro-1-hydroxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid 9H-fluoren-9-ylmethyl ester

There total 3 articles about 2-[(5-chloro-1-hydroxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 887476-51-9
2-[(5-chloro-1-methoxymethoxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid 9H-fluoren-9-ylmethyl ester

: 887476-49-5
2-[(5-chloro-1-hydroxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With ethanethiol; magnesium bromide; In diethyl ether; at 20 ℃; for 4h;
DOI:10.1002/ejoc.200500856

Reference yield:

: 85812-92-6
Boc-L-Phe-OFm

: 887476-49-5
2-[(5-chloro-1-hydroxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: HCl; water / diethyl ether / 1.5 h / 20 °C

2: 0.24 g / N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide*HCl; 1H-benzotriazol-1-ol hydrate; ethyldiisopropylamine / CH₂Cl₂ / 4 h / 20 °C

3: 88 percent / MgBr₂*Et₂O; EtSH / diethyl ether / 4 h / 20 °C

With hydrogenchloride; water; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; ethanethiol; magnesium bromide; In diethyl ether; dichloromethane;
DOI:10.1002/ejoc.200500856

Reference yield:

: 9-fluorenemethyl (S)-phenylalaninate hydrochloride

: 887476-49-5
2-[(5-chloro-1-hydroxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 0.24 g / N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide*HCl; 1H-benzotriazol-1-ol hydrate; ethyldiisopropylamine / CH₂Cl₂ / 4 h / 20 °C

2: 88 percent / MgBr₂*Et₂O; EtSH / diethyl ether / 4 h / 20 °C

With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; ethanethiol; magnesium bromide; In diethyl ether; dichloromethane;
DOI:10.1002/ejoc.200500856