(1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-pyrrolidinecarbonitrile

Base Information

• Chemical Name: (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-pyrrolidinecarbonitrile
• CAS No.: 132235-36-0
• Molecular Formula: C₁₇H₃₀N₂O₂
• Molecular Weight: 294.437
• Mol file: 132235-36-0.mol

Synonyms:(1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-pyrrolidinecarbonitrile

Chemical Property of (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-pyrrolidinecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-pyrrolidinecarbonitrile

There total 2 articles about (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-pyrrolidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-menthol (2216-51-5) → (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-pyrrolidinecarbonitrile (132235-36-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / HCl(g) / pentane / -4 °C

2: 1) CH₃CN, 45 deg C, ultrasound, 48h, 2) CH₃CN, 2h

With hydrogenchloride; In pentane;

Reference yield:

(1R,2S,5R)-1-(chloromethoxy)-2-isopropyl-5-methylcyclohexane (26127-08-2,144177-48-0) + potassium cyanide (151-50-8) + 3,4-dihydro-5-methyl-2H-pyrrole 1-oxide (6931-10-8) → (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-pyrrolidinecarbonitrile (132235-36-0) + (1'R,2R,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-pyrrolidinecarbonitrile (132235-34-8)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given; 1) CH₃CN, 45 deg C, ultrasound, 48h, 2) CH₃CN, 2h;

Reference yield: 68.0%

(1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-pyrrolidinecarbonitrile (132235-36-0) → (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-pyrrolidine carboxamide (132235-40-6)

Guidance literature:

With dihydrogen peroxide; sodium carbonate; In acetone; at 45 ℃; for 18h; ultrasound;

upstream raw materials:

(1R,2S,5R)-1-(chloromethoxy)-2-isopropyl-5-methylcyclohexane

potassium cyanide

3,4-dihydro-5-methyl-2H-pyrrole 1-oxide

(-)-menthol

Downstream raw materials:

(1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-pyrrolidine carboxamide

(S)-2-methylpyrrolidine-2-carboxylic acid amide

(S)-2-methylpyrrolidine-2-carboxylic acid