Octadecanoic acid (R)-2-({2-[3-(4-tert-butoxycarbonylamino-phenyl)-3-methyl-ureido]-ethoxy}-hydroxy-phosphoryloxy)-1-octadecanoyloxymethyl-ethyl ester

Base Information

Chemical Name:Octadecanoic acid (R)-2-({2-[3-(4-tert-butoxycarbonylamino-phenyl)-3-methyl-ureido]-ethoxy}-hydroxy-phosphoryloxy)-1-octadecanoyloxymethyl-ethyl ester
CAS No.:173912-50-0
Molecular Formula:C₅₄H₉₈N₃O₁₁P
Molecular Weight:996.359
Hs Code.:

Octadecanoic acid (R)-2-({2-[3-(4-tert-butoxycarbonylamino-phenyl)-3-methyl-ureido]-ethoxy}-hydroxy-phosphoryloxy)-1-octadecanoyloxymethyl-ethyl ester

Synonyms:Octadecanoic acid (R)-2-({2-[3-(4-tert-butoxycarbonylamino-phenyl)-3-methyl-ureido]-ethoxy}-hydroxy-phosphoryloxy)-1-octadecanoyloxymethyl-ethyl ester

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Chemical Property of Octadecanoic acid (R)-2-({2-[3-(4-tert-butoxycarbonylamino-phenyl)-3-methyl-ureido]-ethoxy}-hydroxy-phosphoryloxy)-1-octadecanoyloxymethyl-ethyl ester

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Technology Process of Octadecanoic acid (R)-2-({2-[3-(4-tert-butoxycarbonylamino-phenyl)-3-methyl-ureido]-ethoxy}-hydroxy-phosphoryloxy)-1-octadecanoyloxymethyl-ethyl ester

There total 4 articles about Octadecanoic acid (R)-2-({2-[3-(4-tert-butoxycarbonylamino-phenyl)-3-methyl-ureido]-ethoxy}-hydroxy-phosphoryloxy)-1-octadecanoyloxymethyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1069-79-0
1,2-distearoyl-sn-glycero-3-phosphoethanolamine

: 123252-11-9
N-<4-((tert-butoxycarbonyl)amino)phenyl>-N-methylcarbamic chloride

: 173912-50-0
Octadecanoic acid (R)-2-({2-[3-(4-tert-butoxycarbonylamino-phenyl)-3-methyl-ureido]-ethoxy}-hydroxy-phosphoryloxy)-1-octadecanoyloxymethyl-ethyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 65 ℃;
DOI:10.1021/jo951350k

Reference yield:

: 1429-59-0,10567-21-2
1,2-distearoyl-sn-glycerol

: 173912-50-0
Octadecanoic acid (R)-2-({2-[3-(4-tert-butoxycarbonylamino-phenyl)-3-methyl-ureido]-ethoxy}-hydroxy-phosphoryloxy)-1-octadecanoyloxymethyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₃N, POCl₃, 2.) Et₃N / 1.) THF, 0 deg C - room temperature, 2.) THF, 0 deg C - room temperature

2: 93 percent / TFA / CH₂Cl₂ / Ambient temperature

3: 91 percent / Et₃N / tetrahydrofuran / 65 °C

With triethylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo951350k

Reference yield:

: 115265-94-6
Octadecanoic acid (R)-2-[(2-tert-butoxycarbonylamino-ethoxy)-hydroxy-phosphoryloxy]-1-octadecanoyloxymethyl-ethyl ester

: 173912-50-0
Octadecanoic acid (R)-2-({2-[3-(4-tert-butoxycarbonylamino-phenyl)-3-methyl-ureido]-ethoxy}-hydroxy-phosphoryloxy)-1-octadecanoyloxymethyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / TFA / CH₂Cl₂ / Ambient temperature

2: 91 percent / Et₃N / tetrahydrofuran / 65 °C

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo951350k