1-phenethyl-4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-4-carboxylic acid ethyl ester

Base Information

Chemical Name:1-phenethyl-4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-4-carboxylic acid ethyl ester
CAS No.:793651-31-7
Molecular Formula:C₂₉H₃₃NO₅S
Molecular Weight:507.651
Hs Code.:

Synonyms:1-phenethyl-4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-4-carboxylic acid ethyl ester

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Chemical Property of 1-phenethyl-4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-4-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 1-phenethyl-4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-4-carboxylic acid ethyl ester

There total 5 articles about 1-phenethyl-4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-4-carboxylate hydrochloride

: 122-78-1
phenylacetaldehyde

: 793651-31-7
1-phenethyl-4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-4-carboxylic acid ethyl ester

Guidance literature:: With borane pyridine; In ethanol; at 20 ℃; for 72h;
DOI:10.1021/jm0500875

Reference yield:

: 213013-98-0
4-(iodomethyl)piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: 793651-31-7
1-phenethyl-4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 0.25 h / 0 °C

1.2: 89 percent / dimethylformamide / 4 h / 0 - 20 °C

2.1: 97 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 2 h / 0 °C

3.1: 80 percent / HCl(gas) / ethyl acetate / 0.08 h / 0 °C

4.1: BH₃*pyridine / ethanol / 72 h / 20 °C

With hydrogenchloride; borane pyridine; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0500875

Reference yield:

: 213014-03-0
4-(4-phenoxy-phenylsulfanylmethyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: 793651-31-7
1-phenethyl-4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 2 h / 0 °C

2: 80 percent / HCl(gas) / ethyl acetate / 0.08 h / 0 °C

3: BH₃*pyridine / ethanol / 72 h / 20 °C

With hydrogenchloride; borane pyridine; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm0500875