ethyl 3-(3-fluorophenyl)-2-(2-(hydroxymethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methylpropanoate

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Chemical Name:ethyl 3-(3-fluorophenyl)-2-(2-(hydroxymethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methylpropanoate
CAS No.:1264295-82-0
Molecular Formula:C₂₆H₂₃F₄N₃O₃
Molecular Weight:501.481
Hs Code.:

Synonyms:ethyl 3-(3-fluorophenyl)-2-(2-(hydroxymethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methylpropanoate

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Chemical Property of ethyl 3-(3-fluorophenyl)-2-(2-(hydroxymethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methylpropanoate

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Technology Process of ethyl 3-(3-fluorophenyl)-2-(2-(hydroxymethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methylpropanoate

There total 8 articles about ethyl 3-(3-fluorophenyl)-2-(2-(hydroxymethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1264296-71-0
ethyl 3-(3-fluorophenyl)-2-(2-(formyloxymethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methylpropanoate

: 1264295-82-0
ethyl 3-(3-fluorophenyl)-2-(2-(hydroxymethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methylpropanoate

Guidance literature:: ethyl 3-(3-fluorophenyl)-2-(2-(formyloxymethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methylpropanoate; With water; sodium hydrogencarbonate; In methanol; at 20 ℃; for 1h;

With hydrogenchloride; In methanol; water;

Reference yield:

: 2338-75-2
4-(Trifluoromethyl)phenylacetonitrile

: 1264295-82-0
ethyl 3-(3-fluorophenyl)-2-(2-(hydroxymethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 2 h / 100 °C

2: hydrazine hydrochloride / ethanol; water / 12 h / 80 °C

3: trifluoroacetic acid / ethanol / 12 h / 80 °C

4: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 12 h / 60 °C

5: sodium iodide / N,N-dimethyl-formamide / 1 h / 80 °C

6: sodium hydrogencarbonate; water / methanol / 1 h / 20 °C

With N-Bromosuccinimide; hydrazine hydrochloride; 2,2'-azobis(isobutyronitrile); water; sodium hydrogencarbonate; trifluoroacetic acid; sodium iodide; In methanol; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1264296-29-8
(Z)-3-(dimethylamino)-2-(4-(trifluoromethyl)phenyl)but-2-enenitrile

: 1264295-82-0
ethyl 3-(3-fluorophenyl)-2-(2-(hydroxymethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrochloride / ethanol; water / 12 h / 80 °C

2: trifluoroacetic acid / ethanol / 12 h / 80 °C

3: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 12 h / 60 °C

4: sodium iodide / N,N-dimethyl-formamide / 1 h / 80 °C

5: sodium hydrogencarbonate; water / methanol / 1 h / 20 °C

With N-Bromosuccinimide; hydrazine hydrochloride; 2,2'-azobis(isobutyronitrile); water; sodium hydrogencarbonate; trifluoroacetic acid; sodium iodide; In methanol; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide;