(E)-ethyl 5-(dimethylamino)-2-(3-fluorobenzyl)-2-methyl-3-oxopent-4-enoate

Base Information

• Chemical Name: (E)-ethyl 5-(dimethylamino)-2-(3-fluorobenzyl)-2-methyl-3-oxopent-4-enoate
• CAS No.: 1264296-28-7
• Molecular Formula: C₁₇H₂₂FNO₃
• Molecular Weight: 307.365

Synonyms:(E)-ethyl 5-(dimethylamino)-2-(3-fluorobenzyl)-2-methyl-3-oxopent-4-enoate

Chemical Property of (E)-ethyl 5-(dimethylamino)-2-(3-fluorobenzyl)-2-methyl-3-oxopent-4-enoate

Chemical Property:

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Technology Process of (E)-ethyl 5-(dimethylamino)-2-(3-fluorobenzyl)-2-methyl-3-oxopent-4-enoate

There total 1 articles about (E)-ethyl 5-(dimethylamino)-2-(3-fluorobenzyl)-2-methyl-3-oxopent-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methyl-3-(methylsulfonyl)-4-phenylbutan-2-one (1264296-25-4) + N,N-dimethylformamide diethyl diacetal (1188-33-6) → (E)-ethyl 5-(dimethylamino)-2-(3-fluorobenzyl)-2-methyl-3-oxopent-4-enoate (1264296-28-7)

Guidance literature:

at 100 ℃; for 12h;

Reference yield:

3-methyl-4-(4-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine (1264296-30-1,1221133-66-9) + (E)-ethyl 5-(dimethylamino)-2-(3-fluorobenzyl)-2-methyl-3-oxopent-4-enoate (1264296-28-7) → ethyl 3-(3-fluorophenyl)-2-methyl-2-(2-methyl-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propanoate (1263940-78-8)

Guidance literature:

With trifluoroacetic acid; In ethanol; at 80 ℃; for 12h;

Reference yield:

3-(methylthio)-4-(4-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine (1264296-73-2) + (E)-ethyl 5-(dimethylamino)-2-(3-fluorobenzyl)-2-methyl-3-oxopent-4-enoate (1264296-28-7) → ethyl 3-(3-fluorophenyl)-2-methyl-2-(2-(methylthio)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propanoate (1264295-85-3)

Guidance literature:

With trifluoroacetic acid; In methanol; at 80 ℃; for 6h;

upstream raw materials:

3-methyl-3-(methylsulfonyl)-4-phenylbutan-2-one

N,N-dimethylformamide diethyl diacetal

Downstream raw materials:

ethyl 2-(2-(bromomethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-3-(3-fluorophenyl)-2-methylpropanoate

ethyl 3-(3-fluorophenyl)-2-(2-(formyloxymethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methylpropanoate

ethyl 3-(3-fluorophenyl)-2-(2-(hydroxymethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methylpropanoate

ethyl 3-(3-fluorophenyl)-2-methyl-2-(2-methyl-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propanoate

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