(-)-ethyl 2-<<<(R)-1-hydroxyprop-2-yl>amino>methylene>-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate

Base Information

Chemical Name:(-)-ethyl 2-<<<(R)-1-hydroxyprop-2-yl>amino>methylene>-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate
CAS No.:110548-04-4
Molecular Formula:C₁₅H₁₅F₄NO₄
Molecular Weight:349.282
Hs Code.:

Synonyms:(-)-ethyl 2-<<<(R)-1-hydroxyprop-2-yl>amino>methylene>-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate

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Chemical Property of (-)-ethyl 2-<<<(R)-1-hydroxyprop-2-yl>amino>methylene>-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate

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Technology Process of (-)-ethyl 2-<<<(R)-1-hydroxyprop-2-yl>amino>methylene>-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate

There total 2 articles about (-)-ethyl 2-<<<(R)-1-hydroxyprop-2-yl>amino>methylene>-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.3%

: 2749-11-3
(S)-Alaninol

: 94695-50-8
ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate

: 122-51-0
orthoformic acid triethyl ester

: 110548-04-4
(-)-ethyl 2-<<<(R)-1-hydroxyprop-2-yl>amino>methylene>-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate

Guidance literature:: ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate; orthoformic acid triethyl ester; at 140 ℃; for 0.5h;

With acetic anhydride; at 140 ℃; for 40h;

(S)-Alaninol; In dichloromethane; at 20 ℃; for 96h;

Reference yield:

: 94695-50-8
ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate

: 110548-04-4
(-)-ethyl 2-<<<(R)-1-hydroxyprop-2-yl>amino>methylene>-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic anhydride / 2 h / 110 °C

2: CH₂Cl₂ / 0.5 h / Ambient temperature

In dichloromethane; acetic anhydride;
DOI:10.1021/jm00395a017