N-(hydroxy(methyl)phosphinyl)-L-phenylalanine, disodium salt

Base Information

• Chemical Name: N-(hydroxy(methyl)phosphinyl)-L-phenylalanine, disodium salt
• CAS No.: 84558-45-2
• Molecular Formula: C₁₀H₁₂NO₄P*2Na
• Molecular Weight: 287.163
• Mol file: 84558-45-2.mol

Synonyms:N-(hydroxy(methyl)phosphinyl)-L-phenylalanine, disodium salt

Chemical Property of N-(hydroxy(methyl)phosphinyl)-L-phenylalanine, disodium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(hydroxy(methyl)phosphinyl)-L-phenylalanine, disodium salt

There total 20 articles about N-(hydroxy(methyl)phosphinyl)-L-phenylalanine, disodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(amino(methyl)phosphinyl)-L-phenylalanine benzyl ester (80556-13-4,84621-23-8,84621-24-9) → N-(hydroxy(methyl)phosphinyl)-L-phenylalanine, disodium salt (84558-45-2)

Guidance literature:

With dipotassium hydrogenphosphate; hydrogen; palladium on activated charcoal; In water; acetone; at 21 ℃; for 0.75h;

DOI:10.1021/ja00344a032

Reference yield:

N-(methoxy(methyl)phosphinyl)-L-phenylalanine methyl ester (84558-46-3,84558-49-6) → N-(hydroxy(methyl)phosphinyl)-L-phenylalanine, disodium salt (84558-45-2)

Guidance literature:

With sodium hydroxide; In water; at 21 ℃; for 24h;

DOI:10.1021/ja00344a032

Reference yield:

C17H19ClNO3P → N-(hydroxy(methyl)phosphinyl)-L-phenylalanine, disodium salt (84558-45-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.22 g / NH₃ gas / CHCl₃ / 0.2 h / 21 °C

2: 1.) H₂, N-methylmorpholine, 2.) NaOD / 5percent Pd/C / 0.5 h / 21 °C / 2.) D₂O

3: 2.0 N NaOD / D₂O / 21 °C

With 4-methyl-morpholine; deuteriated sodium hydroxide; ammonia; hydrogen; palladium on activated charcoal; In chloroform; water-d2;

DOI:10.1021/ja00344a032

upstream raw materials:

methanol

(S_P)-N-(hydroxy(methyl)phosphinothioyl)-L-phenylalanine, disodium salt

N-(hydroxy(methyl)phosphinyl)-L-phenylalanine, bis(triethylammonium) salt

N-(methoxy(methyl)phosphinyl)-L-phenylalanine methyl ester

Downstream raw materials:

L-phenylalanine