4-Phenyl-1,2,3,4-tetrahydroisoquinolin-4-ol

Base Information

Chemical Name:4-Phenyl-1,2,3,4-tetrahydroisoquinolin-4-ol
CAS No.:157017-51-1
Molecular Formula:C₁₅H₁₅NO
Molecular Weight:225.29
Hs Code.:
DSSTox Substance ID:DTXSID901262323
Nikkaji Number:J1.245.761H

Synonyms:4-Phenyl-1,2,3,4-tetrahydroisoquinolin-4-ol;SCHEMBL4009975;SOIZBCZOBJUNFN-UHFFFAOYSA-N;DTXSID901262323;157017-51-1;1,2,3,4-Tetrahydro-4-phenyl-4-isoquinolinol

Suppliers and Price of 4-Phenyl-1,2,3,4-tetrahydroisoquinolin-4-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Phenyl-1,2,3,4-tetrahydroisoquinolin-4-ol

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:225.115364102
Heavy Atom Count:17
Complexity:262

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C2=CC=CC=C2C(CN1)(C3=CC=CC=C3)O

Technology Process of 4-Phenyl-1,2,3,4-tetrahydroisoquinolin-4-ol

There total 4 articles about 4-Phenyl-1,2,3,4-tetrahydroisoquinolin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 3-cyano-3-phenylisobenzofuran-1(3H)-one

: 157017-51-1
4-hydroxy-4-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at -78 - 20 ℃; for 13.5h;

Reference yield: 88.4%

: 137522-29-3
2-Benzyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-4-ol

: 157017-51-1
4-hydroxy-4-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With hydrogenchloride; hydrogen; palladium dihydroxide; In methanol; for 3h; under 760 Torr; Ambient temperature;
DOI:10.1248/cpb.42.67

Reference yield:

: 606-28-0
methyl o-benzoylbenzoate

: 157017-51-1
4-hydroxy-4-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethylaluminium chloride / hexane / 0.5 h / 20 °C

1.2: 1 h / 0 °C

2.1: lithium aluminium tetrahydride / diethyl ether / 13.5 h / -78 - 20 °C

With lithium aluminium tetrahydride; diethylaluminium chloride; In diethyl ether; hexane;