137522-29-3

Upstream product

• 100-46-9 benzylamine 
• 26260-02-6 2-iodobenzaldehyde 
• 70-11-1 α-bromoacetophenone 
• 56008-40-3 N-benzyl-1-(2-iodophenyl)methanamine 
• 131326-81-3 2-[Benzyl-(2-iodo-benzyl)-amino]-1-phenyl-ethanone 

Downstream Products

• 157017-51-1 4-hydroxy-4-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 68858-27-5 12-phenyl-7,12-dihydro-5H-6,12-methano-dibenzo[c,f]azocine 
• 87522-38-1 2-benzyl-4-phenylisoquinolin-1(2H)-one 
• 261784-61-6 2-Benzyl-4-phenyl-1,2-dihydro-isoquinoline 

Relevant academic research and scientific papers

A convenient synthesis of 4-substituted 1,2,3,4-tetrahydroisoquinolin-4-ols by a novel intramolecular Barbier reaction and by an insertion reaction: Reaction scope and limitations

4-Substituted 1,2,3,4-tetrahydroisoquinolin-4-ols were prepared from N-(2-iodobenzyl)phenacylamines by an intramolecular Barbier reaction with butyllithium and by an insertion reaction with zerovalent nickel. The scope and limitations of these reactions were discussed.

A NEW SYNTHESIS OF 7,12-DIHYDRO-12-PHENYL-5H-6,12-METHANODIBENZAZOCINES VIA N-BENZYL-1,2,3,4-TETRAHYDRO-4-PHENYLISOQUINOLIN-4-OLS

7,12-Dihydro-12-phenyl-5H-6,12-methanodibenzazocine derivatives were prepared from N-benzyl-1,2,3,4-tetrahydro-4-phenylisoquinolin-4-ols by an intramolecular Friedel-Crafts reaction.

A NEW INTRAMOLECULAR BARBIER REACTION OF N-(2-IODOBENZYL)PHENACYLAMINES: A CONVENIENT SYNTHESIS OF 1,2,3,4-TETRAHYDROISOQUINOLIN-4-OLS

4-Phenyl-1,2,3,4-tetrahydroisoquinolin-4-ols were prepared by an intramolecular Barbier reaction of N-(2-iodobenzyl)phenacylamines with butyllithium in good yields.