3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carbaldehyde

Base Information

Chemical Name:3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carbaldehyde
CAS No.:852615-25-9
Molecular Formula:C₂₂H₂₄N₂O₆S
Molecular Weight:444.508
Hs Code.:

Synonyms:3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carbaldehyde

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Chemical Property of 3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carbaldehyde

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Technology Process of 3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carbaldehyde

There total 10 articles about 3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 852615-24-8
3-(3,4-dimethoxybenzyl)-4-(hydroxymethyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-1,3-dihydro-imidazol-2-one

: 852615-25-9
3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carbaldehyde

Guidance literature:: With manganese(IV) oxide; In dichloromethane; at 25 ℃; for 12h;
DOI:10.1021/ol0473602

Reference yield:

: 852615-22-6
2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carboxylic acid methyl ester

: 852615-25-9
3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / K₂CO₃ / dimethylformamide / 65 °C

2: DIBAl-H / CH₂Cl₂ / -78 °C

3: activated manganese dioxide / CH₂Cl₂

With manganese(IV) oxide; diisobutylaluminium hydride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.12.068

Reference yield:

: 7306-46-9
4-chloromethyl-1,2-dimethoxy-benzene

: 852615-25-9
3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / K₂CO₃ / dimethylformamide / 65 °C

2: DIBAl-H / CH₂Cl₂ / -78 °C

3: activated manganese dioxide / CH₂Cl₂

With manganese(IV) oxide; diisobutylaluminium hydride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.12.068