3-(3,4-dimethoxybenzyl)-4-(3-hydroxypropenyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-1,3-dihydro-imidazol-2-one

Base Information

Chemical Name:3-(3,4-dimethoxybenzyl)-4-(3-hydroxypropenyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-1,3-dihydro-imidazol-2-one
CAS No.:852615-07-7
Molecular Formula:C₂₄H₂₈N₂O₆S
Molecular Weight:472.562
Hs Code.:

Synonyms:3-(3,4-dimethoxybenzyl)-4-(3-hydroxypropenyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-1,3-dihydro-imidazol-2-one

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Chemical Property of 3-(3,4-dimethoxybenzyl)-4-(3-hydroxypropenyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-1,3-dihydro-imidazol-2-one

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Technology Process of 3-(3,4-dimethoxybenzyl)-4-(3-hydroxypropenyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-1,3-dihydro-imidazol-2-one

There total 12 articles about 3-(3,4-dimethoxybenzyl)-4-(3-hydroxypropenyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-1,3-dihydro-imidazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852615-26-0
3-{3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazol-4-yl}-acrylic acid ethyl ester

: 852615-07-7
3-(3,4-dimethoxybenzyl)-4-(3-hydroxypropenyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-1,3-dihydro-imidazol-2-one

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 1.5h;
DOI:10.1021/ol0473602

Reference yield:

: 852615-22-6
2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carboxylic acid methyl ester

: 852615-07-7
3-(3,4-dimethoxybenzyl)-4-(3-hydroxypropenyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-1,3-dihydro-imidazol-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / K₂CO₃ / dimethylformamide / 65 °C

2.1: DIBAl-H / CH₂Cl₂ / -78 °C

3.1: activated manganese dioxide / CH₂Cl₂

4.1: NaH / tetrahydrofuran / 0 - 25 °C

4.2: tetrahydrofuran / 2 h

5.1: DIBAl-H / CH₂Cl₂ / -78 °C

With manganese(IV) oxide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 4.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.tet.2005.12.068

Reference yield:

: 852615-25-9
3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carbaldehyde

: 852615-07-7
3-(3,4-dimethoxybenzyl)-4-(3-hydroxypropenyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-1,3-dihydro-imidazol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0 - 25 °C

1.2: tetrahydrofuran / 2 h

2.1: DIBAl-H / CH₂Cl₂ / -78 °C

With sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; 1.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.tet.2005.12.068