(3-Fluoro-5-(trifluoromethyl)phenyl)boronic acid

Base Information

• Chemical Name: (3-Fluoro-5-(trifluoromethyl)phenyl)boronic acid
• CAS No.: 159020-59-4
• Molecular Formula: C7H5BF4O2
• Molecular Weight: 207.92
• Hs Code.: 29310099
• European Community (EC) Number: 640-289-6
• DSSTox Substance ID: DTXSID00382499
• Wikidata: Q82173854
• Mol file: 159020-59-4.mol

Synonyms:159020-59-4;(3-Fluoro-5-(trifluoromethyl)phenyl)boronic acid;3-Fluoro-5-(trifluoromethyl)phenylboronic acid;3-FLUORO-5-TRIFLUOROMETHYLPHENYLBORONIC ACID;[3-fluoro-5-(trifluoromethyl)phenyl]boronic Acid;3-FLUORO-5-(TRIFLUOROMETHYL)BENZENEBORONIC ACID;3-(Trifluoromethyl)-5-fluorophenylboronic acid;(3-Fluoro-5-Trifluoromethylphenyl)Boronic Acid;MFCD06657735;3-FLUORO-5-(TRIFLUOROMETHYL)BENZENE BORONIC ACID;3-Borono-5-fluorobenzotrifluoride;Hexyl4-Hydroxybenzoate;5-Fluoro-3-trifluoromethylbenzeneboronic acid;SCHEMBL491507;DTXSID00382499;AKOS006222093;AB25665;AM85419;CS-W015249;AS-17805;SY007862;F1064;FT-0643546;3-fluoro-5-trifluoromethylbenzene boronic acid;3-fluoro-5-trifluoromethylphenyl boronic acid;3-fluoro-5-trifluoromethylphenyl-boronic acid;3-fluoro-5-trifluoromethyl-phenyl-boronic acid;EN300-7372661;A809992;J-502747;3-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]BORONIC ACID;Boronic acid, B-[3-fluoro-5-(trifluoromethyl)phenyl]-;3-(trifluoromethyl)-5-fluoro-phenylboronic acid, AldrichCPR;3-Fluoro-5-(trifluoromethyl)phenylboronic Acid (contains varying amounts of Anhydride)

Chemical Property of (3-Fluoro-5-(trifluoromethyl)phenyl)boronic acid

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Melting Point: 168°C(lit.)
• Refractive Index: 1.445
• Boiling Point: 264 °C at 760 mmHg
• PKA: 6.52±0.10(Predicted)
• Flash Point: 113.5 °C
• PSA: 40.46000
• Density: 1.44 g/cm³
• LogP: 0.52430
• Storage Temp.: Keep Cold
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 208.0318722
• Heavy Atom Count: 14
• Complexity: 197

Purity/Quality:

99% ^*data from raw suppliers

3-Fluoro-5-trifluoromethylphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B(C1=CC(=CC(=C1)F)C(F)(F)F)(O)O
• Uses: suzuki reaction

Technology Process of (3-Fluoro-5-(trifluoromethyl)phenyl)boronic acid

There total 2 articles about (3-Fluoro-5-(trifluoromethyl)phenyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-5-fluorobenzotrifluoride (130723-13-6) + 3-fluoro-5-trifluoromethylphenyl bromide-tetrahydrofuran + Trimethyl borate (121-43-7,63156-11-6) → (3-fluoro-5-(trifluoromethyl)phenyl)boronic acid (159020-59-4)

Guidance literature:

With iodine; magnesium; In tetrahydrofuran; water;

Reference yield:

3-bromo-5-fluorobenzotrifluoride (130723-13-6) + 3-fluoro-5-trifluoromethylphenyl bromide-tetrahydrofuran + Trimethyl borate (121-43-7,63156-11-6) → (3-fluoro-5-(trifluoromethyl)phenyl)boronic acid (159020-59-4)

Guidance literature:

With magnesium; In tetrahydrofuran; water;

Reference yield: 86.0%

(3-fluoro-5-(trifluoromethyl)phenyl)boronic acid (159020-59-4) + α-bromo-α-fluorophenylethanone (321-75-5) → 2-fluoro-2-(3-fluoro-5-(trifluoromethyl)phenyl)-1-phenylethan-1-one

Guidance literature:

With nickel(II) triflate; 1,10-Phenanthroline; potassium carbonate; In 1,4-dioxane; at 80 ℃; for 8h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b02474

upstream raw materials:

3-bromo-5-fluorobenzotrifluoride

Trimethyl borate

Downstream raw materials:

ethyl 3-[2-[3-fluoro-5-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]benzoate

ethyl (2E)-3-{5-[3-fluoro-5-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate

ethyl 6-(3-fluoro-5-(trifluoromethyl)phenyl)-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 159020-59-4 3-FLUORO-5-(TRIFLUOROMETHYL)BENZENE BORONIC ACID

Send

Send

Metric Ton KG G Pound L ML

Send

Send