2-[3-[[(propylamino)sulfonyl]amino]phenoxy]-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]-benzamide

Base Information

Chemical Name:2-[3-[[(propylamino)sulfonyl]amino]phenoxy]-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]-benzamide
CAS No.:1084332-51-3
Molecular Formula:C₂₂H₂₁F₂IN₄O₄S
Molecular Weight:602.4
Hs Code.:

Synonyms:2-[3-[[(propylamino)sulfonyl]amino]phenoxy]-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]-benzamide

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Chemical Property of 2-[3-[[(propylamino)sulfonyl]amino]phenoxy]-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]-benzamide

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Technology Process of 2-[3-[[(propylamino)sulfonyl]amino]phenoxy]-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]-benzamide

There total 5 articles about 2-[3-[[(propylamino)sulfonyl]amino]phenoxy]-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 10305-42-7
N-propylsulfamoyl chloride

: 1084332-21-7
2-(3-amino-phenoxy)-4-fluoro-6-(2-fluoro-4-iodo-phenylamino)-benzamide

: 1084332-51-3
2-[3-[[(propylamino)sulfonyl]amino]phenoxy]-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]-benzamide

Guidance literature:: 2-(3-amino-phenoxy)-4-fluoro-6-(2-fluoro-4-iodo-phenylamino)-benzamide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;

N-propylsulfamoyl chloride; In dichloromethane; at 0 - 20 ℃; for 3.5h;

N-propylsulfamoyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 48h;

Reference yield:

: 19962-06-2
tert-butyl 3-hydroxyphenylcarbamate

: 1084332-51-3
2-[3-[[(propylamino)sulfonyl]amino]phenoxy]-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 17 h / 0 - 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 22.5 h / 3 - 20 °C

3.1: sodium hydroxide / water; dimethyl sulfoxide

3.2: 2.33 h / 63 - 65 °C

4.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

5.2: 3.5 h / 0 - 20 °C

5.3: 48 h / 20 °C

With sodium hydroxide; potassium tert-butylate; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1084332-51-3
2-[3-[[(propylamino)sulfonyl]amino]phenoxy]-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 22.5 h / 3 - 20 °C

2.1: sodium hydroxide / water; dimethyl sulfoxide

2.2: 2.33 h / 63 - 65 °C

3.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

4.2: 3.5 h / 0 - 20 °C

4.3: 48 h / 20 °C

With sodium hydroxide; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;