2-(Chloromethyl)-2-imidazoline

Base Information

• Chemical Name: 2-(Chloromethyl)-2-imidazoline
• CAS No.: 50342-08-0
• Molecular Formula: C4H7 Cl N2
• Molecular Weight: 118.566
• Hs Code.: 2933290090
• Mol file: 50342-08-0.mol

Synonyms:2-(Chloromethyl)-2-imidazoline;2-(Chloromethyl)-4,5-dihydroimidazole

Chemical Property of 2-(Chloromethyl)-2-imidazoline

Chemical Property:

• Vapor Pressure: 0.0222mmHg at 25°C
• Melting Point: 72-73 ºC
• Boiling Point: 258 ºC
• Flash Point: 110 ºC
• PSA: 24.39000
• Density: 1.36
• LogP: -0.00870

Purity/Quality:

98%Min ^*data from raw suppliers

2-(CHLOROMETHYL)-4,5-DIHYDRO-1H-IMIDAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Chloromethyl)-2-imidazoline

There total 2 articles about 2-(Chloromethyl)-2-imidazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4,5-dihydro-1H-imidazol-2-yl)-methanol; hydrochloride (95185-87-8) → 2-(chloromethyl)-imidazoline (50342-08-0)

Guidance literature:

With thionyl chloride;

Reference yield:

ethyl chloroacetimidate hydrochloride (36743-66-5) + ethylenediamine (107-15-3,85404-18-8) → 2-(chloromethyl)-imidazoline (50342-08-0)

Guidance literature:

With ethanol;

Reference yield: 73.0%

2-benzylbenzimidazole (621-72-7) + 2-(chloromethyl)-imidazoline (50342-08-0) → 2-benzyl-1-((4,5-dihydro-1H-imidazol-2-yl)methyl)-1H-benzimidazole (1355356-75-0)

Guidance literature:

2-benzylbenzimidazole; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.25h;

2-(chloromethyl)-imidazoline; In tetrahydrofuran; mineral oil; at 20 ℃; for 6h;

DOI:10.1016/j.bmc.2011.11.025

upstream raw materials:

(4,5-dihydro-1H-imidazol-2-yl)-methanol; hydrochloride

ethyl chloroacetimidate hydrochloride

ethylenediamine

Downstream raw materials:

midaglizole

diphenyl-acetic acid-(4,5-dihydro-1H-imidazol-2-ylmethyl ester); hydrochloride

2-phenylthiomethyl-2-imidazoline

2-benzhydryloximethyl-4,5-dihydro-1H-imidazole