2-cyano-5-methyl-N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide

Base Information

• Chemical Name: 2-cyano-5-methyl-N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide
• CAS No.: 1426214-83-6
• Molecular Formula: C₂₀H₁₆N₆O₂S
• Molecular Weight: 404.452
• Mol file: 1426214-83-6.mol

Synonyms:2-cyano-5-methyl-N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide

Chemical Property of 2-cyano-5-methyl-N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyano-5-methyl-N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide

There total 10 articles about 2-cyano-5-methyl-N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-carbamic acid tert-butyl ester (1426214-82-5) + 2-cyano-5-methylbenzene-1-sulfonyl chloride (197960-31-9) → 2-cyano-5-methyl-N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide (1426214-83-6)

Guidance literature:

[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-carbamic acid tert-butyl ester; With hydrogenchloride; In water; at 20 ℃; for 2h;

2-cyano-5-methylbenzene-1-sulfonyl chloride; With pyridine; at 100 ℃; for 0.5h; Sealed tube;

Reference yield: 21.0%

→ 2-cyano-5-methyl-N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide (1426214-83-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 - 25 ℃; for 2h;

With pyridine; at 100 ℃; for 0.5h; Sealed tube;

In N,N-dimethyl-formamide;

Reference yield:

C12H11N5 + 2-cyano-5-methylbenzene-1-sulfonyl chloride (197960-31-9) → 2-cyano-5-methyl-N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide (1426214-83-6)

Guidance literature:

With pyridine; at 100 ℃; for 0.5h; Sealed tube;

upstream raw materials:

3,5-dichloro-pyrazine-2-carbonitrile

[4-(tert-butoxycarbonylamino)phenyl]boronic acid

2-cyano-5-methylbenzene-1-sulfonyl chloride

[4-(5-acetyl-6-chloro-pyrazin-2-yl)-phenyl]-carbamic acid tert-butyl ester