3,5-Dichloropyrazine-2-carbonitrile

Base Information

• Chemical Name: 3,5-Dichloropyrazine-2-carbonitrile
• CAS No.: 313339-92-3
• Molecular Formula: C5HCl2N3
• Molecular Weight: 173.989
• Hs Code.: 2933990090
• Mol file: 313339-92-3.mol

Synonyms:2-pyrazinecarbonitrile, 3,5-dichloro-;LogP

Chemical Property of 3,5-Dichloropyrazine-2-carbonitrile

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.591
• Boiling Point: 276.627 °C at 760 mmHg
• PKA: -8.85±0.10(Predicted)
• Flash Point: 121.1 °C
• PSA: 49.57000
• Density: 1.607 g/cm³
• LogP: 1.65508
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,5-Dichloropyrazine-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Dichloropyrazine-2-carbonitrile

There total 2 articles about 3,5-Dichloropyrazine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.6%

3,5-dichloropyrazine-2-carboxamide (312736-50-8) → 3,5-dichloro-pyrazine-2-carbonitrile (313339-92-3)

Guidance literature:

With trichlorophosphate; for 5h; Time; Reflux;

Reference yield: 56.0%

(E)-1-(3,5-dichloropyrazin-2-yl)-N-hydroxymethanimine (1207852-78-5) → 3,5-dichloro-pyrazine-2-carbonitrile (313339-92-3)

Guidance literature:

With thionyl chloride; at 20 - 80 ℃; for 4h;

Reference yield: 100.0%

3,5-dichloro-pyrazine-2-carbonitrile (313339-92-3) + tert-butyl (3S)-3-aminopiperidine-1-carboxylate (625471-18-3) → tert-butyl (3S)-3-[(6-chloro-5-cyanopyrazin-2-yl)amino]piperidine-1-carboxylate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Time;

upstream raw materials:

(E)-1-(3,5-dichloropyrazin-2-yl)-N-hydroxymethanimine

3,5-dichloropyrazine-2-carboxamide

Downstream raw materials:

2,3-dichloro-N-[4-(6-chloro-5-cyano-pyrazin-2-yl)phenyl]benzenesulfonamide

[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-carbamic acid tert-butyl ester

N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-cyano-5-methylbenzenesulfonamide

N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl) phenyl]-2-chloro-5-methoxy-benzenesulfonamide

Refernces

• 1、 -. "CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF". Paragraph 0725; 0726. . Retrieved 2018/02/28.
• 2、 -. "NOVEL IMIDAZOTRIAZINONE OR IMIDAZOPYRAZINONE DERIVATIVES, AND USE THEREOF". Paragraph 461-463. . Retrieved 2016/04/26.