N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactyl-L-pipecolyl-D-lactic acid

Base Information

Chemical Name:N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactyl-L-pipecolyl-D-lactic acid
CAS No.:187851-87-2
Molecular Formula:C₅₁H₇₄N₄O₁₃
Molecular Weight:951.168
Hs Code.:

Synonyms:N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactyl-L-pipecolyl-D-lactic acid

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Chemical Property of N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactyl-L-pipecolyl-D-lactic acid

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Technology Process of N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactyl-L-pipecolyl-D-lactic acid

There total 9 articles about N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactyl-L-pipecolyl-D-lactic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 188908-43-2
1-[2-(4-methyl-2-{methyl-[2-(4-methyl-2-{methyl-[2-(4-methyl-2-methylamino-pentanoyloxy)-3-phenyl-propionyl]-amino}-pentanoyloxy)-propionyl]-amino}-pentanoyloxy)-3-phenyl-propionyl]-piperidine-2-carboxylic acid 1-benzyloxycarbonyl-ethyl ester

: 187851-87-2
N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactyl-L-pipecolyl-D-lactic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 3h; under 2327.17 - 2585.74 Torr;
DOI:10.1021/jm020482k

Reference yield:

: 26250-84-0
(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid

: 187851-87-2
N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactyl-L-pipecolyl-D-lactic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 24 percent / DEAD; Ph₃P / diethyl ether / 1 h / 20 °C

2: 74 percent / CF₃CO₂H / CH₂Cl₂ / 1 h / 25 °C

3: 24 percent / DIC; DMAP / CH₂Cl₂ / 16 h / 20 °C

4: 84 percent / CF₃CO₂H / CH₂Cl₂ / 1 h / 25 °C

5: 88 percent / H₂ / Pd/C / ethanol / 3 h / 2327.17 - 2585.74 Torr

With dmap; hydrogen; dacarbazine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane; 1: Mitsunobu reaction;
DOI:10.1021/jm020482k

Reference yield:

: 157567-63-0
benzyl N-methyl-L-leucyl-3-phenyl-D-lactate

: 187851-87-2
N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactyl-L-pipecolyl-D-lactic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 52 percent / DIC; DMAP / CH₂Cl₂ / 20 °C

2: 81 percent / H₂ / Pd/C / ethanol / 3 h / 2327.17 - 2585.74 Torr

3: 24 percent / DIC; DMAP / CH₂Cl₂ / 16 h / 20 °C

4: 84 percent / CF₃CO₂H / CH₂Cl₂ / 1 h / 25 °C

5: 88 percent / H₂ / Pd/C / ethanol / 3 h / 2327.17 - 2585.74 Torr

With dmap; hydrogen; dacarbazine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm020482k