N-[2-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-yl)-1-methyl-ethyl]-phthalimide

Base Information

• Chemical Name: N-[2-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-yl)-1-methyl-ethyl]-phthalimide
• CAS No.: 60640-16-6
• Molecular Formula: C₂₇H₂₀ClN₅O₂
• Molecular Weight: 481.941

Synonyms:N-[2-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-yl)-1-methyl-ethyl]-phthalimide

Chemical Property of N-[2-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-yl)-1-methyl-ethyl]-phthalimide

Chemical Property:

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Technology Process of N-[2-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-yl)-1-methyl-ethyl]-phthalimide

There total 4 articles about N-[2-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-yl)-1-methyl-ethyl]-phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid N'-(7-chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-yl)-hydrazide (63333-73-3) → N-[2-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-yl)-1-methyl-ethyl]-phthalimide (60640-16-6)

Guidance literature:

In acetic acid; at 117 ℃; for 0.7h; Yield given;

DOI:10.1021/jm00178a009

Reference yield:

7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine (18091-89-9,112393-62-1) → N-[2-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-yl)-1-methyl-ethyl]-phthalimide (60640-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) carbonyldiimidazole / 1.) THF, RT, 72 min, 2.) THF, RT, 18 h

2: acetic acid / 0.7 h / 117 °C

With 1,1'-carbonyldiimidazole; In acetic acid;

DOI:10.1021/jm00178a009

Reference yield:

3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)butyric acid (4443-37-2) → N-[2-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-yl)-1-methyl-ethyl]-phthalimide (60640-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) carbonyldiimidazole / 1.) THF, RT, 72 min, 2.) THF, RT, 18 h

2: acetic acid / 0.7 h / 117 °C

With 1,1'-carbonyldiimidazole; In acetic acid;

DOI:10.1021/jm00178a009

upstream raw materials:

3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid N'-(7-chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-yl)-hydrazide

7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine

3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)butyric acid

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