4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(chloroacetyl)glycinanilide

Base Information

• Chemical Name: 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(chloroacetyl)glycinanilide
• CAS No.: 59180-42-6
• Molecular Formula: C₁₈H₁₅Cl₃N₂O₃
• Molecular Weight: 413.688
• Mol file: 59180-42-6.mol

Synonyms:4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(chloroacetyl)glycinanilide

Chemical Property of 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(chloroacetyl)glycinanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(chloroacetyl)glycinanilide

There total 5 articles about 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(chloroacetyl)glycinanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-glycinanilide hydrobromide (59180-41-5) + chloroacetyl chloride (79-04-9) → 4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(chloroacetyl)glycinanilide (59180-42-6)

Guidance literature:

In N,N,N,N,N,N-hexamethylphosphoric triamide; for 5h;

DOI:10.1021/jm00133a006

Reference yield:

4-chloro-2-(o-chlorobenzoyl)-Nα-(benzyloxycarbonyl)glycinanilide (29176-39-4) → 4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(chloroacetyl)glycinanilide (59180-42-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) sodium hydride (50percent oil dispersion) / DMF, RT

2: 96.5 percent / 20percent HBr-AcOH / Ambient temperature

3: 89 percent / dimethylformamide / Ambient temperature

With hydrogen bromide; sodium hydride; acetic acid; In N,N-dimethyl-formamide;

Reference yield:

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(benzyloxycarbonyl)glycinanilide (74601-56-2) → 4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(chloroacetyl)glycinanilide (59180-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 96.5 percent / 20percent HBr-AcOH / Ambient temperature

2: 89 percent / dimethylformamide / Ambient temperature

With hydrogen bromide; acetic acid; In N,N-dimethyl-formamide;

upstream raw materials:

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-glycinanilide hydrobromide

chloroacetyl chloride

4-chloro-2-(o-chlorobenzoyl)-N^α-(benzyloxycarbonyl)glycinanilide

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(benzyloxycarbonyl)glycinanilide

Downstream raw materials:

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(phthalylglycyl)glycinanilide

N-({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-2-(4-phenyl-piperazin-1-yl)-acetamide

N-({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-2-phenethylamino-acetamide

N-({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-2-(4-methyl-piperazin-1-yl)-acetamide