N-(4-fluorophenyl)butyramide

Base Information

• Chemical Name: N-(4-fluorophenyl)butyramide
• CAS No.: 35369-63-2
• Molecular Formula: C₁₀H₁₂FNO
• Molecular Weight: 181.21
• Mol file: 35369-63-2.mol

Synonyms:N-(4-fluorophenyl)butyramide

Chemical Property of N-(4-fluorophenyl)butyramide

Chemical Property:

Purity/Quality:

N-(4-FLUOROPHENYL)BUTANAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-fluorophenyl)butyramide

There total 4 articles about N-(4-fluorophenyl)butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-fluoroaniline (371-40-4) + butyric acid (107-92-6) → N-(4-fluorophenyl)butyramide (35369-63-2)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jacs.9b03291

Reference yield:

butyryl chloride (141-75-3) + 4-fluoroaniline (371-40-4) → N-(4-fluorophenyl)butyramide (35369-63-2)

Guidance literature:

4-fluoroaniline; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.333333h;

butyryl chloride; In tetrahydrofuran; at 20 ℃; for 13h;

DOI:10.1021/acs.orglett.7b00893

Reference yield:

butyraldehyde oxime (110-69-0) + 4-fluoroaniline (371-40-4) → N-(4-fluorophenyl)butyramide (35369-63-2)

Guidance literature:

With nickel(II) chloride hexahydrate; In para-xylene; at 155 ℃; for 18h; Inert atmosphere;

DOI:10.1021/ol101978h

upstream raw materials:

butanoic acid anhydride

4-fluoroaniline

butyraldehyde oxime

butyryl chloride

Downstream raw materials:

N-butyl-4-fluoroaniline

Refernces

• 1、 He, Zhi-Tao,Hartwig, John F.. "Palladium-Catalyzed α-Arylation of Carboxylic Acids and Secondary Amides via a Traceless Protecting Strategy". supporting information. p. 11749 - 11753. Retrieved 2019/08/26.
• 2、 Allen, C. Liana,Davulcu, Simge,Williams, Jonathan M. J.. "Catalytic acylation of amines with aldehydes or aldoximes". supporting information; experimental part. p. 5096 - 5099. Retrieved 2011/02/21.