ethyl (S)-3-phenyl-4-[4-[3-(pyridin-2-yl)amino-1-propyloxy]phenyl]butanoate

Base Information

• Chemical Name: ethyl (S)-3-phenyl-4-[4-[3-(pyridin-2-yl)amino-1-propyloxy]phenyl]butanoate
• CAS No.: 243642-05-9
• Molecular Formula: C₂₆H₃₀N₂O₃
• Molecular Weight: 418.536
• Mol file: 243642-05-9.mol

Synonyms:ethyl (S)-3-phenyl-4-[4-[3-(pyridin-2-yl)amino-1-propyloxy]phenyl]butanoate

Chemical Property of ethyl (S)-3-phenyl-4-[4-[3-(pyridin-2-yl)amino-1-propyloxy]phenyl]butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (S)-3-phenyl-4-[4-[3-(pyridin-2-yl)amino-1-propyloxy]phenyl]butanoate

There total 7 articles about ethyl (S)-3-phenyl-4-[4-[3-(pyridin-2-yl)amino-1-propyloxy]phenyl]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

Ethyl-(S)-3-phenyl-4-[4-[3-(1-oxopyridin-2-yl)amino-1-propyloxy]phenyl]butanoate (243642-04-8) → ethyl (S)-3-phenyl-4-[4-[3-(pyridin-2-yl)amino-1-propyloxy]phenyl]butanoate (243642-05-9)

Guidance literature:

With palladium on activated charcoal; cyclohexene; In isopropyl alcohol;

DOI:10.1016/S0960-894X(03)00102-1

Reference yield:

2-(4-methoxyphenyl)acetophenone (24845-40-7) → ethyl (S)-3-phenyl-4-[4-[3-(pyridin-2-yl)amino-1-propyloxy]phenyl]butanoate (243642-05-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 96 percent / LiN(TMS)2 / tetrahydrofuran

2.1: Et₃Si; BF₃*OEt₂ / CH₂Cl₂

2.2: 91 percent / H₂ / 10 percent Pd/C / ethanol

3.1: EtSH; AlCl₃ / CH₂Cl₂

4.1: 38 percent / NaH / dimethylsulfoxide

5.1: 100 percent / TFA / CH₂Cl₂

6.1: 43 percent / cyclohexene; 10 percent Pd/C / propan-2-ol

With triethylsilane; palladium on activated charcoal; aluminium trichloride; boron trifluoride diethyl etherate; sodium hydride; trifluoroacetic acid; ethanethiol; lithium hexamethyldisilazane; cyclohexene; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; isopropyl alcohol; 3.2: chiral HPLC resolution;

DOI:10.1016/S0960-894X(03)00102-1

Reference yield:

2-(3-hydroxypropyl)aminopyridine-N-oxide (187339-14-6) → ethyl (S)-3-phenyl-4-[4-[3-(pyridin-2-yl)amino-1-propyloxy]phenyl]butanoate (243642-05-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 98 percent / 2-methyl-propan-2-ol

2: 64 percent / pyridine / CHCl₃

3: 38 percent / NaH / dimethylsulfoxide

4: 100 percent / TFA / CH₂Cl₂

5: 43 percent / cyclohexene; 10 percent Pd/C / propan-2-ol

With pyridine; palladium on activated charcoal; sodium hydride; trifluoroacetic acid; cyclohexene; In dichloromethane; chloroform; dimethyl sulfoxide; isopropyl alcohol; tert-butyl alcohol;

DOI:10.1016/S0960-894X(03)00102-1

upstream raw materials:

Ethyl-(S)-3-phenyl-4-[4-[3-(1-oxopyridin-2-yl)amino-1-propyloxy]phenyl]butanoate

2-(4-methoxyphenyl)acetophenone

2-(3-hydroxypropyl)aminopyridine-N-oxide

2-[N-(3-hydroxy-1-propyl)-N-(tert-butoxycarbonyl)amino]pyridine-N-oxide