6-benzyloxy-3-chloromethyl-1-[5-(benzofuran-2-carboxamido)indole-2-carbonyl]indoline

Base Information

Chemical Name:6-benzyloxy-3-chloromethyl-1-[5-(benzofuran-2-carboxamido)indole-2-carbonyl]indoline
CAS No.:351890-39-6
Molecular Formula:C₃₄H₂₆ClN₃O₄
Molecular Weight:576.051
Hs Code.:

Synonyms:6-benzyloxy-3-chloromethyl-1-[5-(benzofuran-2-carboxamido)indole-2-carbonyl]indoline

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Chemical Property of 6-benzyloxy-3-chloromethyl-1-[5-(benzofuran-2-carboxamido)indole-2-carbonyl]indoline

Chemical Property:

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Technology Process of 6-benzyloxy-3-chloromethyl-1-[5-(benzofuran-2-carboxamido)indole-2-carbonyl]indoline

There total 3 articles about 6-benzyloxy-3-chloromethyl-1-[5-(benzofuran-2-carboxamido)indole-2-carbonyl]indoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.4%

: 110314-42-6
5-(benzofuran-2-ylcarbonyl)amino-1H-indole-2-carboxylic acid

: 351890-37-4
6-benzyloxy-3-(chloromethyl)indoline

: 351890-39-6
6-benzyloxy-3-chloromethyl-1-[5-(benzofuran-2-carboxamido)indole-2-carbonyl]indoline

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1515/HC.2001.7.1.7

Reference yield:

: 106014-83-9
2-[4-(benzyloxy)-2-nitrophenyl]propane-1,3-diol

: 351890-39-6
6-benzyloxy-3-chloromethyl-1-[5-(benzofuran-2-carboxamido)indole-2-carbonyl]indoline

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / triphenylphosphine; CCl₄ / CH₂Cl₂ / 20 °C

2: SnCl₂*2H₂O; concd. HCl / tetrahydrofuran

3: 35.4 percent / EDCI / dimethylformamide / 20 °C

With hydrogenchloride; tetrachloromethane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; tin(ll) chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1515/HC.2001.7.1.7

Reference yield:

: 351890-36-3
2-[4-benzyloxy-2-nitrophenyl]-1,3-dichloropropane

: 351890-39-6
6-benzyloxy-3-chloromethyl-1-[5-(benzofuran-2-carboxamido)indole-2-carbonyl]indoline

Guidance literature:: Multi-step reaction with 2 steps

1: SnCl₂*2H₂O; concd. HCl / tetrahydrofuran

2: 35.4 percent / EDCI / dimethylformamide / 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tin(ll) chloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1515/HC.2001.7.1.7