C₂₀H₂₂ClNO₄

Base Information

Chemical Name:C₂₀H₂₂ClNO₄
CAS No.:1258864-04-8
Molecular Formula:C₂₀H₂₂ClNO₄
Molecular Weight:375.852
Hs Code.:

C<sub>20</sub>H<sub>22</sub>ClNO<sub>4</sub>

Synonyms:C₂₀H₂₂ClNO₄

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Chemical Property of C₂₀H₂₂ClNO₄

Chemical Property:

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Technology Process of C₂₀H₂₂ClNO₄

There total 12 articles about C₂₀H₂₂ClNO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1258864-03-7
C₂₀H₂₄ClNO₄

: 1258864-04-8
C₂₀H₂₂ClNO₄

Guidance literature:: With 1-methyl-2-azaadamantane-N-oxyl; [bis(acetoxy)iodo]benzene; In dichloromethane; at 20 ℃; for 12h;
DOI:10.3987/COM-10-12042

Reference yield:

: C₉H₁₇NO₂

: 1258864-04-8
C₂₀H₂₂ClNO₄

Guidance literature:: Multi-step reaction with 11 steps

1.1: dmap; triethylamine / dichloromethane / 0.5 h / 20 °C

1.2: 2 h / 20 °C

2.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene / water; acetonitrile / 15 h / 0 °C

3.1: methanol / diethyl ether / 0 °C

4.1: toluene-4-sulfonic acid / toluene / 12 h / Reflux

5.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C

5.2: 0.25 h

6.1: sodium tetrahydroborate / methanol / 2 h / -40 °C

7.1: pyridinium p-toluenesulfonate / dichloromethane / 3 h / Reflux

8.1: diisobutylaluminium hydride / tetrahydrofuran / 9 h / -5 °C

9.1: dmap; triethylamine / dichloromethane / 3 h / Reflux

10.1: dimethylaluminum chloride / hexane; dichloromethane / 0.5 h / 0 - 20 °C

11.1: 1-methyl-2-azaadamantane-N-oxyl; [bis(acetoxy)iodo]benzene / dichloromethane / 12 h / 20 °C

With methanol; dmap; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium tetrahydroborate; 1-methyl-2-azaadamantane-N-oxyl; [bis(acetoxy)iodo]benzene; dimethylaluminum chloride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; toluene; acetonitrile; 5.1: Claisen condensation / 5.2: Claisen condensation;
DOI:10.3987/COM-10-12042

Reference yield:

: 1258863-99-8
C₁₆H₂₀ClNO₃

: 1258864-04-8
C₂₀H₂₂ClNO₄

Guidance literature:: Multi-step reaction with 10 steps

1.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene / water; acetonitrile / 15 h / 0 °C

2.1: methanol / diethyl ether / 0 °C

3.1: toluene-4-sulfonic acid / toluene / 12 h / Reflux

4.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C

4.2: 0.25 h

5.1: sodium tetrahydroborate / methanol / 2 h / -40 °C

6.1: pyridinium p-toluenesulfonate / dichloromethane / 3 h / Reflux

7.1: diisobutylaluminium hydride / tetrahydrofuran / 9 h / -5 °C

8.1: dmap; triethylamine / dichloromethane / 3 h / Reflux

9.1: dimethylaluminum chloride / hexane; dichloromethane / 0.5 h / 0 - 20 °C

10.1: 1-methyl-2-azaadamantane-N-oxyl; [bis(acetoxy)iodo]benzene / dichloromethane / 12 h / 20 °C

With methanol; dmap; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium tetrahydroborate; 1-methyl-2-azaadamantane-N-oxyl; [bis(acetoxy)iodo]benzene; dimethylaluminum chloride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; toluene; acetonitrile; 4.1: Claisen condensation / 4.2: Claisen condensation;
DOI:10.3987/COM-10-12042