2-amino-7-methoxy-6-[2-methyl-5-(3-trifluoromethylbenzamide)phenyl]-8-phenylquinazoline

Base Information

Chemical Name:2-amino-7-methoxy-6-[2-methyl-5-(3-trifluoromethylbenzamide)phenyl]-8-phenylquinazoline
CAS No.:1191929-31-3
Molecular Formula:C₃₀H₂₃F₃N₄O₂
Molecular Weight:528.533
Hs Code.:

Synonyms:2-amino-7-methoxy-6-[2-methyl-5-(3-trifluoromethylbenzamide)phenyl]-8-phenylquinazoline

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Chemical Property of 2-amino-7-methoxy-6-[2-methyl-5-(3-trifluoromethylbenzamide)phenyl]-8-phenylquinazoline

Chemical Property:

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Technology Process of 2-amino-7-methoxy-6-[2-methyl-5-(3-trifluoromethylbenzamide)phenyl]-8-phenylquinazoline

There total 8 articles about 2-amino-7-methoxy-6-[2-methyl-5-(3-trifluoromethylbenzamide)phenyl]-8-phenylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1191932-18-9
2-amino-8-bromo-7-methoxy-6-[2-methyl-5-((3-trifluoromethyl)benzamido)phenyl]quinazoline

: 98-80-6
phenylboronic acid

: 1191929-31-3
2-amino-7-methoxy-6-[2-methyl-5-(3-trifluoromethylbenzamide)phenyl]-8-phenylquinazoline

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; for 5.5h; Reflux;

Reference yield:

: 876322-58-6
N-[4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3-trifluoromethyl-benzamide

: 1191929-31-3
2-amino-7-methoxy-6-[2-methyl-5-(3-trifluoromethylbenzamide)phenyl]-8-phenylquinazoline

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / Reflux

2: N-Bromosuccinimide / chloroform; acetic acid / 3 h / 20 °C

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 5.5 h / Reflux

With N-Bromosuccinimide; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; chloroform; water; acetic acid;

Reference yield:

: 882670-69-1
4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine

: 1191929-31-3
2-amino-7-methoxy-6-[2-methyl-5-(3-trifluoromethylbenzamide)phenyl]-8-phenylquinazoline

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0.17 h / 0 °C

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / Reflux

3: N-Bromosuccinimide / chloroform; acetic acid / 3 h / 20 °C

4: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 5.5 h / Reflux

With N-Bromosuccinimide; sodium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; chloroform; water; acetic acid;