876322-58-6

Basic information

• Product Name: N-[4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3-trifluoromethyl-benzamide
• Synonyms: N-[4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3-trifluoromethyl-benzamide
• CAS NO: 876322-58-6
• Molecular Weight: 405.225
• Mol File: 876322-58-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 427.2±45.0 °C(Predicted)
• Density: 1.22±0.1 g/cm3(Predicted)
• CAS DataBase Reference: N-[4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3-trifluoromethyl-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3-trifluoromethyl-benzamide(876322-58-6)
• EPA Substance Registry System: N-[4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3-trifluoromethyl-benzamide(876322-58-6)

Safety Data

• Hazardous Substances Data: 876322-58-6(Hazardous Substances Data)

Upstream product

• 876322-59-7 N-(3-bromo-4-methylphenyl)-3-(trifluoromethyl)benzamide 
• 73183-34-3 bis(pinacol)diborane 
• 882670-69-1 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine 
• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 
• 35944-64-0 3-iodo-4-methylaniline 

Downstream Products

• 1238376-14-1 N-[3-(3-amino-1H-indazol-6-yl)-4-methylphenyl]-3-(trifluoromethyl)benzamide 
• 1191932-17-8 2-amino-7-methoxy-6-[2-methyl-5-((3-trifluoromethyl)benzamido)phenyl]quinazoline 
• 1191932-18-9 2-amino-8-bromo-7-methoxy-6-[2-methyl-5-((3-trifluoromethyl)benzamido)phenyl]quinazoline 
• 1191929-32-4 2-amino-7-methoxy-6-[2-methyl-5-(3-trifluoromethylbenzamide)phenyl]-8-(2-pyridyl)quinazoline 
• 1191929-31-3 2-amino-7-methoxy-6-[2-methyl-5-(3-trifluoromethylbenzamide)phenyl]-8-phenylquinazoline 
• 1191929-34-6 2-amino-7-hydroxy-6-[2-methyl-5-(3-trifluoromethylbenzamide)phenyl]-8-(2-pyridyl)quinazoline 

Relevant articles and documents

Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors

A series of imidazo[1,2-a]pyridin-6-yl-benzamide analogs was designed as inhibitors of B-RAFV600E. Medicinal chemistry techniques were employed to explore the SAR for this series and improve selectivity versus P38 and VEGFR2.

DERIVATIVES OF 1 H-PYRAZOLO[3,4-B]PYRIDINE AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS

The present invention discloses compounds according to Formula (I): wherein R1, R2, R3, R4, L, and X are as defined herein. The present invention relates to compounds,methods for their production, pharmaceutical

BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS

The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.