4-(tert-butyl(dimethyl)silanyloxy)-2-((6-chloropyridin-3-yl)methyl)butyric acid phenyl ester

Base Information

Chemical Name:4-(tert-butyl(dimethyl)silanyloxy)-2-((6-chloropyridin-3-yl)methyl)butyric acid phenyl ester
CAS No.:658057-65-9
Molecular Formula:C₂₂H₃₀ClNO₃Si
Molecular Weight:420.024
Hs Code.:

Synonyms:4-(tert-butyl(dimethyl)silanyloxy)-2-((6-chloropyridin-3-yl)methyl)butyric acid phenyl ester

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Chemical Property of 4-(tert-butyl(dimethyl)silanyloxy)-2-((6-chloropyridin-3-yl)methyl)butyric acid phenyl ester

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Technology Process of 4-(tert-butyl(dimethyl)silanyloxy)-2-((6-chloropyridin-3-yl)methyl)butyric acid phenyl ester

There total 4 articles about 4-(tert-butyl(dimethyl)silanyloxy)-2-((6-chloropyridin-3-yl)methyl)butyric acid phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 244628-26-0
2-chloro-5-(iodomethyl)pyridine

: 658057-64-8
4-(tert-butyl(dimethyl)silanyloxy)butyric acid phenyl ester

: 658057-65-9
4-(tert-butyl(dimethyl)silanyloxy)-2-((6-chloropyridin-3-yl)methyl)butyric acid phenyl ester

Guidance literature:: 4-(tert-butyl(dimethyl)silanyloxy)butyric acid phenyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

2-chloro-5-(iodomethyl)pyridine; With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jo035457g

Reference yield:

: 70258-18-3
2-chloro-5-(chloromethyl)pyridine

: 658057-65-9
4-(tert-butyl(dimethyl)silanyloxy)-2-((6-chloropyridin-3-yl)methyl)butyric acid phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaI / acetone

2.1: LDA / tetrahydrofuran / -78 °C

2.2: 30 percent / HMPA / tetrahydrofuran / 20 °C

With sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; acetone;
DOI:10.1021/jo035457g

Reference yield:

: 69171-62-6
4-(tert-butyl(dimethyl)silanyloxy)butyric acid

: 658057-65-9
4-(tert-butyl(dimethyl)silanyloxy)-2-((6-chloropyridin-3-yl)methyl)butyric acid phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 80 percent / DCC; DMAP / CH₂Cl₂

2.1: LDA / tetrahydrofuran / -78 °C

2.2: 30 percent / HMPA / tetrahydrofuran / 20 °C

With dmap; dicyclohexyl-carbodiimide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo035457g