{3-[3-(Cyclohexyl-methyl-carbamoyl)-propoxy]-2-nitro-benzylamino}-acetic acid ethyl ester

Base Information

• Chemical Name: {3-[3-(Cyclohexyl-methyl-carbamoyl)-propoxy]-2-nitro-benzylamino}-acetic acid ethyl ester
• CAS No.: 1071163-51-3
• Molecular Formula: C₂₂H₃₃N₃O₆
• Molecular Weight: 435.521
• Mol file: 1071163-51-3.mol

Synonyms:{3-[3-(Cyclohexyl-methyl-carbamoyl)-propoxy]-2-nitro-benzylamino}-acetic acid ethyl ester

Chemical Property of {3-[3-(Cyclohexyl-methyl-carbamoyl)-propoxy]-2-nitro-benzylamino}-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {3-[3-(Cyclohexyl-methyl-carbamoyl)-propoxy]-2-nitro-benzylamino}-acetic acid ethyl ester

There total 7 articles about {3-[3-(Cyclohexyl-methyl-carbamoyl)-propoxy]-2-nitro-benzylamino}-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{[1-{3-[3-(Cyclohexyl-methyl-carbamoyl)-propoxy]-2-nitro-phenyl}-meth-(E)-ylidene]-amino}-acetic acid ethyl ester → {3-[3-(Cyclohexyl-methyl-carbamoyl)-propoxy]-2-nitro-benzylamino}-acetic acid ethyl ester (1071163-51-3)

Guidance literature:

With sodium cyanoborohydride; In ethanol; for 3h;

DOI:10.1021/jm00385a012

Reference yield:

N-methylcyclohexylamine (100-60-7) → {3-[3-(Cyclohexyl-methyl-carbamoyl)-propoxy]-2-nitro-benzylamino}-acetic acid ethyl ester (1071163-51-3)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. Na₂CO₃ / tetrahydrofuran / 1 h / Ambient temperature

2: 1.) AcONa / ethanol / 0.5 h

3: NaBH₃CN / ethanol / 3 h

With sodium acetate; sodium cyanoborohydride; sodium carbonate; In tetrahydrofuran; ethanol;

DOI:10.1021/jm00385a012

Reference yield:

3-hydroxy-2-nitrobenzaldehyde (42123-33-1) → {3-[3-(Cyclohexyl-methyl-carbamoyl)-propoxy]-2-nitro-benzylamino}-acetic acid ethyl ester (1071163-51-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 38 percent / K₂CO₃ / dimethylformamide

2: 51 percent / aq. KOH

3: oxalyl chloride / benzene; dimethylformamide / 0.5 h

4: aq. Na₂CO₃ / tetrahydrofuran / 1 h / Ambient temperature

5: 1.) AcONa / ethanol / 0.5 h

6: NaBH₃CN / ethanol / 3 h

With potassium hydroxide; oxalyl dichloride; sodium acetate; sodium cyanoborohydride; sodium carbonate; potassium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; benzene;

DOI:10.1021/jm00385a012

upstream raw materials:

N-methylcyclohexylamine

3-hydroxy-2-nitrobenzaldehyde

4-(2-nitro-3-formylphenyl)oxybutanoic acid

4-(3-Formyl-2-nitro-phenoxy)-butyric acid ethyl ester

Downstream raw materials:

N-cyclohexyl-N-methyl-4-(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-9-yl)oxybutyramide