4-Bromo-3-hydroxypyridine

Base Information

• Chemical Name: 4-Bromo-3-hydroxypyridine
• CAS No.: 161417-28-3
• Molecular Formula: C5H4BrNO
• Molecular Weight: 173.997
• Hs Code.: 2933399090
• European Community (EC) Number: 806-483-1
• DSSTox Substance ID: DTXSID30376205
• Wikidata: Q72457017
• Mol file: 161417-28-3.mol

Synonyms:4-Bromo-3-hydroxypyridine;161417-28-3;4-bromopyridin-3-ol;3-Pyridinol, 4-bromo-;MFCD03093021;MFCD08741481;4-Bromo-3-pyridinol;4bromo-3-pyridinol;SCHEMBL316645;DTXSID30376205;YCVSFCXUHPVAFH-UHFFFAOYSA-N;2,6-Dimethylphenylthiosemicarbazide;AKOS005199009;AB13187;AC-3227;CS-W006061;DS-10526;SY004894;AM20080743;BB 0260702;FT-0617834;A18265;EN300-123127;J-009827;J-514729

Chemical Property of 4-Bromo-3-hydroxypyridine

Chemical Property:

• Appearance/Colour: White solid
• Vapor Pressure: 0.000225mmHg at 25°C
• Melting Point: 134-136 °C
• Refractive Index: 1.614
• Boiling Point: 316.2 °C at 760 mmHg
• PKA: 6.57±0.10(Predicted)
• Flash Point: 145 °C
• PSA: 33.12000
• Density: 1.788 g/cm³
• LogP: 1.54970
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Sparingly), Ethyl Acetate
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 172.94763
• Heavy Atom Count: 8
• Complexity: 78.8

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-3-hydroxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC(=C1Br)O

Technology Process of 4-Bromo-3-hydroxypyridine

There total 3 articles about 4-Bromo-3-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-bromo-pyridin-3-yl diethylcarbamate (98976-81-9) → 4-bromo-3-hydroxypyridine (161417-28-3)

Guidance literature:

With sodium methylate; In methanol;

Reference yield:

C10H12BrNO2 → 4-bromo-3-hydroxypyridine (161417-28-3)

Guidance literature:

With pyridinium p-toluenesulfonate; In methanol; at 20 ℃; for 16h;

DOI:10.1021/jo902666w

Reference yield:

3,4-dihydroxypyridine (10182-48-6) → 4-bromo-3-hydroxypyridine (161417-28-3)

Guidance literature:

With phosphorus(V) oxybromide; at 130 ℃;

upstream raw materials:

3,4-dihydroxypyridine

4-bromo-pyridin-3-yl diethylcarbamate

Downstream raw materials:

acetic acid 4-bromo-pyridin-3-yl ester

5-chloro-2,3-dihydrofuro[2,3-c]pyridine

furo<2,3-c>pyridine

4-bromo-3-(cyclopropylmethoxy)pyridine

Refernces

• 1、 -. "Preparation of heterocyclic ethers as neuronal nicotinic receptor ligands.". . . Retrieved 2008/06/13.