{2-(benzyloxy)-5-[(1R,S)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)ethyl]phenyl}formamide

Base Information

• Chemical Name: {2-(benzyloxy)-5-[(1R,S)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)ethyl]phenyl}formamide
• CAS No.: 1021156-29-5
• Molecular Formula: C₃₉H₄₈F₂N₂O₄Si
• Molecular Weight: 674.903

Synonyms:{2-(benzyloxy)-5-[(1R,S)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)ethyl]phenyl}formamide

Chemical Property of {2-(benzyloxy)-5-[(1R,S)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)ethyl]phenyl}formamide

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Technology Process of {2-(benzyloxy)-5-[(1R,S)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)ethyl]phenyl}formamide

There total 1 articles about {2-(benzyloxy)-5-[(1R,S)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)ethyl]phenyl}formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(2R,S)-1-[4-(2,2-difluoro-2-phenylethoxy)phenyl]propan-2-amine (1021156-28-4) → {2-(benzyloxy)-5-[(1R,S)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)ethyl]phenyl}formamide (1021156-29-5)

Guidance literature:

With potassium carbonate; sodium iodide; In dimethyl sulfoxide; at 125 ℃; for 1h;

Reference yield: 81.0%

{2-(benzyloxy)-5-[(1R,S)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)ethyl]phenyl}formamide (1021156-29-5) → {2-(benzyloxy)-5-[(1R,S)-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)-1-hydroxyethyl]phenyl}formamide (1021156-30-8)

Guidance literature:

With tetrabutyl ammonium fluoride; water; In tetrahydrofuran; at 45 ℃; for 3h;

upstream raw materials:

(2R,S)-1-[4-(2,2-difluoro-2-phenylethoxy)phenyl]propan-2-amine

Downstream raw materials:

{2-(benzyloxy)-5-[(1R,S)-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)-1-hydroxyethyl]phenyl}formamide

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