{2-(benzyloxy)-5-[(1R,S)-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)-1-hydroxyethyl]phenyl}formamide

Base Information

Chemical Name:{2-(benzyloxy)-5-[(1R,S)-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)-1-hydroxyethyl]phenyl}formamide
CAS No.:1021156-30-8
Molecular Formula:C₃₃H₃₄F₂N₂O₄
Molecular Weight:560.641
Hs Code.:

Synonyms:{2-(benzyloxy)-5-[(1R,S)-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)-1-hydroxyethyl]phenyl}formamide

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Chemical Property of {2-(benzyloxy)-5-[(1R,S)-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)-1-hydroxyethyl]phenyl}formamide

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Technology Process of {2-(benzyloxy)-5-[(1R,S)-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)-1-hydroxyethyl]phenyl}formamide

There total 1 articles about {2-(benzyloxy)-5-[(1R,S)-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)-1-hydroxyethyl]phenyl}formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1021156-29-5
{2-(benzyloxy)-5-[(1R,S)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)ethyl]phenyl}formamide

: 1021156-30-8
{2-(benzyloxy)-5-[(1R,S)-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)-1-hydroxyethyl]phenyl}formamide

Guidance literature:: With tetrabutyl ammonium fluoride; water; In tetrahydrofuran; at 45 ℃; for 3h;

Reference yield: 37.0%

: 1021156-30-8
{2-(benzyloxy)-5-[(1R,S)-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)-1-hydroxyethyl]phenyl}formamide

: 16712-16-6,64165-14-6,65387-22-6,70179-79-2,540-69-2
ammonium formate

: 1021155-89-4
{5-[(1R,S)-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)-1-hydroxyethyl]-2-hydroxyphenyl}formamide formic acid salt

Guidance literature:: {2-(benzyloxy)-5-[(1R,S)-2-({(1R,S)-2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]-1-methylethyl}amino)-1-hydroxyethyl]phenyl}formamide; With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In ethanol; under 2070.21 Torr;

ammonium formate; In water; acetonitrile;