Chemical Property of Favipiravir
Chemical Property:
- Boiling Point:552.6 °C at 760 mmHg
- PKA:8.77±0.60(Predicted)
- Flash Point:288 °C
- PSA：88.84000
- Density:1.78 g/cm3
- LogP:-0.29180
- Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
- Solubility.:Soluble in DMSO (30 mg/mL), water (12 mg/mL with warming)
- XLogP3:-0.6
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:1
- Exact Mass:157.02875454
- Heavy Atom Count:11
- Complexity:282
- Purity/Quality:
-
99% *data from raw suppliers
Favipiravir *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1=C(N=C(C(=O)N1)C(=O)N)F
- Recent ClinicalTrials:Favipiravir +/- Nitazoxanide: Early Antivirals Combination Therapy in COVID-19
- Recent EU Clinical Trials:A Phase 3, Multicenter, Prospective, Placebo-Controlled, Randomized, Double-Blind Study to Assess the Efficacy and Safety of Favipiravir in Non-critical Hospitalized Patients with COVID-19 Pneumonia (PROVIR)
- Recent NIPH Clinical Trials:Single Ascending-dose Study of Injectable Favipiravir
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Description
Favipiravir, 6-fluoro-3-hydroxypyrazine-2-carboxamide, is a new broad-spectrum antiviral drug targeting RNA-dependent RNA polymerase (RdRp) developed by Japan's Toyama Chemical Pharmaceutical Company. It was approved for marketing in Japan in March 2014 for the treatment of new and recurrent influenza. During the outbreak of the new coronavirus, the results of the Phase I clinical study of the drug published in March 2020 showed that the drug may have the effect of speeding up virus clearance to alleviate the progress of new coronavirus pneumonia.
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Uses
Favipiravir is used for the treatment of advanced Ebola virus infection in a small animal model. It suppressed the replication of Zaire Ebola virus and prevented a lethal outcome in 100% of the animals. Based on the studies, Favipiravir can be a candidate for the treatment of Ebola hemorrhagic fever. Favipiravir can be used for antiviral treatment of influenza A and B. Studies have shown that in addition to influenza virus, the drug also exhibits good antiviral activity against a variety of RNA viruses, such as Ebola virus, arena virus, Bunia virus, rabies virus and now COVID-19.
