Pyrazinecarboxamide, 3-amino-6-fluoro- (9CI)

Base Information

• Chemical Name: Pyrazinecarboxamide, 3-amino-6-fluoro- (9CI)
• CAS No.: 356783-42-1
• Molecular Formula: C5H5 F N4 O
• Molecular Weight: 156.119
• Hs Code.: 2934999090
• Mol file: 356783-42-1.mol

Synonyms:Pyrazinecarboxamide,3-amino-6-fluoro- (9CI); 3-Amino-6-fluoro-2-pyrazinecarboxamide

Chemical Property of Pyrazinecarboxamide, 3-amino-6-fluoro- (9CI)

Chemical Property:

• PSA: 94.89000
• LogP: 0.57830

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-6-fluoropyrazine-2-carboxamide 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazinecarboxamide, 3-amino-6-fluoro- (9CI)

There total 3 articles about Pyrazinecarboxamide, 3-amino-6-fluoro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

oxalyl dichloride (79-37-8) + 3,6-dichloro-2-pyrazinecarboxylic acid (356783-15-8) → 3-amino-6-fluoro-2-pyrazinecarboxamide (356783-42-1)

Guidance literature:

With ammonium hydroxide; potassium fluoride; sodium chloride; 18-crown-6 ether; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

3-aminopyrazine-2-carboxamide (32587-10-3) → 3-amino-6-fluoro-2-pyrazinecarboxamide (356783-42-1)

Guidance literature:

With sodium bicarbonate; sodium chloride; fluorine; In water; ethyl acetate; trifluoroacetic acid;

Reference yield:

methyl 3-amino-6-fluoro-2-pyrazinecarboxylate (356783-41-0) → 3-amino-6-fluoro-2-pyrazinecarboxamide (356783-42-1)

Guidance literature:

With ammonium hydroxide; In methanol; diethyl ether;

upstream raw materials:

oxalyl dichloride

3,6-dichloro-2-pyrazinecarboxylic acid

methyl 3-amino-6-fluoro-2-pyrazinecarboxylate

3-aminopyrazine-2-carboxamide

Downstream raw materials:

favipiravir

Refernces