1-(4-chloro-2-nitro-5-pyrazol-1-yl-phenyl)-1H-[1,2,4]triazole-3,5-dicarboxylic acid diethyl ester

Base Information

• Chemical Name: 1-(4-chloro-2-nitro-5-pyrazol-1-yl-phenyl)-1H-[1,2,4]triazole-3,5-dicarboxylic acid diethyl ester
• CAS No.: 366804-14-0
• Molecular Formula: C₁₇H₁₅ClN₆O₆
• Molecular Weight: 434.796

Synonyms:1-(4-chloro-2-nitro-5-pyrazol-1-yl-phenyl)-1H-[1,2,4]triazole-3,5-dicarboxylic acid diethyl ester

Chemical Property of 1-(4-chloro-2-nitro-5-pyrazol-1-yl-phenyl)-1H-[1,2,4]triazole-3,5-dicarboxylic acid diethyl ester

Chemical Property:

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Technology Process of 1-(4-chloro-2-nitro-5-pyrazol-1-yl-phenyl)-1H-[1,2,4]triazole-3,5-dicarboxylic acid diethyl ester

There total 5 articles about 1-(4-chloro-2-nitro-5-pyrazol-1-yl-phenyl)-1H-[1,2,4]triazole-3,5-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

[(4-chloro-2-nitro-5-pyrazol-1-yl-phenyl)-hydrazono]-(ethoxyoxalyl-amino)-acetic acid ethyl ester (366804-12-8) → 1-(4-chloro-2-nitro-5-pyrazol-1-yl-phenyl)-1H-[1,2,4]triazole-3,5-dicarboxylic acid diethyl ester (366804-14-0)

Guidance literature:

With sulfuric acid; at 20 ℃; for 12h;

DOI:10.1021/jm010862q

Reference yield:

4,5-dichloro-2-nitroaniline (6641-64-1) → 1-(4-chloro-2-nitro-5-pyrazol-1-yl-phenyl)-1H-[1,2,4]triazole-3,5-dicarboxylic acid diethyl ester (366804-14-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 86 percent / KOH / dimethylformamide / 6 h / 100 °C

2.1: H₂SO₄; aq. NaNO₂ / 0.25 h / 0 °C

2.2: aq. NaBF₄ / 0.5 h / 0 °C

2.3: 63 percent / methanol / 3 h / 20 °C

3.1: 92 percent / NH₃ / dioxane / 20 °C

4.1: 91 percent / toluene / Heating

5.1: 50 percent / H₂SO₄ / 12 h / 20 °C

With potassium hydroxide; sulfuric acid; ammonia; sodium nitrite; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm010862q

Reference yield:

4-chloro-2-nitro-5-pyrazol-1-yl-phenylamine (366804-06-0) → 1-(4-chloro-2-nitro-5-pyrazol-1-yl-phenyl)-1H-[1,2,4]triazole-3,5-dicarboxylic acid diethyl ester (366804-14-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: H₂SO₄; aq. NaNO₂ / 0.25 h / 0 °C

1.2: aq. NaBF₄ / 0.5 h / 0 °C

1.3: 63 percent / methanol / 3 h / 20 °C

2.1: 92 percent / NH₃ / dioxane / 20 °C

3.1: 91 percent / toluene / Heating

4.1: 50 percent / H₂SO₄ / 12 h / 20 °C

With sulfuric acid; ammonia; sodium nitrite; In 1,4-dioxane; toluene;

DOI:10.1021/jm010862q

upstream raw materials:

[(4-chloro-2-nitro-5-pyrazol-1-yl-phenyl)-hydrazono]-(ethoxyoxalyl-amino)-acetic acid ethyl ester

4,5-dichloro-2-nitroaniline

4-chloro-2-nitro-5-pyrazol-1-yl-phenylamine

C₁₃H₁₃ClN₆O₄

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