6641-64-1Relevant articles and documents
A convenient copper-catalyzed direct animation of nitroarenes with 9-alkylhydroxylamines
Seko, Shinzo,Miyake, Kunihito,Kavvamura, Norio
, p. 1437 - 1444 (2007/10/03)
O-Alkylhydroxylamines, particularly O-methylhydroxylamine, aminate nitroarenes in the presence of a strong base and a copper catalyst to give aminonitroarenes in good yields, ortho- or para-Animation with respect to the nitro group takes place, and in some cases the ortho-aminated product is preferentially obtained. With 3-substituted nitrobenzenes where the substituent has a lone pair of electrons, preferential amination occurs at the 2-position to give the sterically most congested 3c-f, 14 and 22g.
2-(Guanidino)-anilides and related compounds. Synthesis and anthelmintic activity. 3rd Communication: Anthelmintics
Wollweber,Kolling,Niemers,et al.
, p. 531 - 542 (2007/10/02)
Anilides bearing a guanidino, thioallophanato, isothioallophanato or amidino group in the ortho position were synthesized for investigations of their anthelmintic effects, and tested against sheep trichostrongylides. The most active anilides are those containing a 5-alkylthio, 5-alkylsulphinyl (alkyl = C3H7, C4H9), 5-phenylthio, 5-phenylsulphinyl or 4-phenylsulphonyloxy group, and a guanidino group substituted at both nitrogen atoms by a methoxycarbonyl group. The most active anthelmintic anilides are the form-, propion-, butyr- and methoxy-acetanilides. Of the guanidines unsubstituted at N' and N'', the 2-guanidino-5-phenylthio-2-methoxyacetanilide and the 2-guanidino-5-phenylsulphinyl-2-methoxyacetanilide were more active than parbendazole. From the class of bismethoxycarbonylguanidines, which are also the most interesting products in terms of stability, febantel (Rintal) has been introduced into veterinary practice for the treatment of nematode infections in horses, cattle, sheep and swine.
Process for the production of 2-aryl-2H-benzotriazoles
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, (2008/06/13)
A process for the production of 2-aryl-2H-benzotriazoles comprises reducing and cyclizing the corresponding o-nitroazobenzenes with hydrogen at a temperature in the range of about 20° C. to about 100° C. and at a pressure in the range of about 15 psia (1 atmosphere) to about 1000 psia (66 atmospheres) in an organic solvent mixture containing an organic amine at a pH over 10 in the presence of noble metal hydrogenation catalyst, preferably palladium. High yields of pure product are obtained with a concomitant reduction of undesired by-products and a reduction in effluent pollution problems.
