(Z)-3-(3-(3-cyano-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylohydrazide

Base Information

Chemical Name:(Z)-3-(3-(3-cyano-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylohydrazide
CAS No.:1388842-34-9
Molecular Formula:C₁₃H₉F₃N₆O
Molecular Weight:322.249
Hs Code.:

Synonyms:(Z)-3-(3-(3-cyano-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylohydrazide

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Chemical Property of (Z)-3-(3-(3-cyano-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylohydrazide

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Technology Process of (Z)-3-(3-(3-cyano-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylohydrazide

There total 10 articles about (Z)-3-(3-(3-cyano-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 328-67-6
3-bromo-5-(trifluoromethyl)benzoic acid

: 1388842-34-9
(Z)-3-(3-(3-cyano-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylohydrazide

Guidance literature:: Multi-step reaction with 10 steps

1.1: N,N-dimethyl-formamide / 150 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 °C

3.1: ammonia / tetrahydrofuran / 0 °C

4.1: sodium hydrogen sulfide; magnesium chloride / N,N-dimethyl-formamide / 20 °C

5.1: hydrazine hydrate / N,N-dimethyl-formamide / 20 °C

5.2: 20 - 90 °C

6.1: trichlorophosphate / N,N-dimethyl-formamide / 25 °C

7.1: 1,4-diaza-bicyclo[2.2.2]octane / N,N-dimethyl-formamide / 25 °C

8.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

9.1: 4-methyl-morpholine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

10.1: hydrazine hydrate / 1 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; 1,4-diaza-bicyclo[2.2.2]octane; sodium hydrogen sulfide; oxalyl dichloride; ammonia; water; hydrazine hydrate; magnesium chloride; lithium hydroxide; trichlorophosphate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 942077-16-9
3-cyano-5-(trifluoromethyl)benzoic acid

: 1388842-34-9
(Z)-3-(3-(3-cyano-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylohydrazide

Guidance literature:: Multi-step reaction with 9 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 °C

2.1: ammonia / tetrahydrofuran / 0 °C

3.1: sodium hydrogen sulfide; magnesium chloride / N,N-dimethyl-formamide / 20 °C

4.1: hydrazine hydrate / N,N-dimethyl-formamide / 20 °C

4.2: 20 - 90 °C

5.1: trichlorophosphate / N,N-dimethyl-formamide / 25 °C

6.1: 1,4-diaza-bicyclo[2.2.2]octane / N,N-dimethyl-formamide / 25 °C

7.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

8.1: 4-methyl-morpholine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

9.1: hydrazine hydrate / 1 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; 1,4-diaza-bicyclo[2.2.2]octane; sodium hydrogen sulfide; oxalyl dichloride; ammonia; water; hydrazine hydrate; magnesium chloride; lithium hydroxide; trichlorophosphate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1333152-56-9
(Z)-isopropyl 3-(3-(3-cyano-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

: 1388842-34-9
(Z)-3-(3-(3-cyano-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: water; lithium hydroxide / tetrahydrofuran / 20 °C

2: 4-methyl-morpholine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3: hydrazine hydrate / 1 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; water; hydrazine hydrate; lithium hydroxide; In tetrahydrofuran;