(2R,5S)-5-Allyloxy-2-benzyloxy-6-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-hexanenitrile

Base Information

Chemical Name:(2R,5S)-5-Allyloxy-2-benzyloxy-6-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-hexanenitrile
CAS No.:211758-03-1
Molecular Formula:C₂₂H₃₁NO₄
Molecular Weight:373.492
Hs Code.:

Synonyms:(2R,5S)-5-Allyloxy-2-benzyloxy-6-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-hexanenitrile

Suppliers and Price of (2R,5S)-5-Allyloxy-2-benzyloxy-6-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-hexanenitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,5S)-5-Allyloxy-2-benzyloxy-6-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-hexanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,5S)-5-Allyloxy-2-benzyloxy-6-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-hexanenitrile

There total 14 articles about (2R,5S)-5-Allyloxy-2-benzyloxy-6-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-hexanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 7677-24-9
trimethylsilyl cyanide

: 211758-02-0
(R)-4-((S)-2-Allyloxy-5,5-bis-benzyloxy-pentyl)-2,2,4-trimethyl-[1,3]dioxolane

: 211758-03-1
(2R,5S)-5-Allyloxy-2-benzyloxy-6-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-hexanenitrile

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -45 ℃;
DOI:10.1016/S0040-4039(98)00971-X

Reference yield:

: 211758-06-4
(S)-6-Methyl-hept-6-ene-1,4-diol

: 211758-03-1
(2R,5S)-5-Allyloxy-2-benzyloxy-6-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-hexanenitrile

Guidance literature:: Multi-step reaction with 9 steps

1: 98 percent / imidazole / CH₂Cl₂ / 0 °C

2: 21 percent / I₂, nBuLi / tetrahydrofuran

3: 92 percent / KOH / 1,2-dimethoxy-ethane

4: 84 percent / KH, Bu₄NI / 1,2-dimethoxy-ethane / 0 °C

5: 68 percent / H₂SO₄

6: 64 percent / NaH / dimethylformamide

7: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, -78 deg C, 2) CH₂Cl₂, -78 to 0 deg C

8: 62 percent / TMSOTf / CH₂Cl₂ / -78 °C

9: 66 percent / TMSOTf / CH₂Cl₂ / -45 °C

With 1H-imidazole; potassium hydroxide; n-butyllithium; oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; iodine; tetra-(n-butyl)ammonium iodide; potassium hydride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)00971-X

Reference yield:

: 211757-95-8
(R)-5-(2-Methyl-allyl)-5H-furan-2-one

: 211758-03-1
(2R,5S)-5-Allyloxy-2-benzyloxy-6-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-hexanenitrile

Guidance literature:: Multi-step reaction with 11 steps

1: 90 percent / NaBH₄, CuCl*2H₂O / methanol / 0 °C

2: 92 percent / LiAlH₄ / tetrahydrofuran / 0 °C

3: 98 percent / imidazole / CH₂Cl₂ / 0 °C

4: 21 percent / I₂, nBuLi / tetrahydrofuran

5: 92 percent / KOH / 1,2-dimethoxy-ethane

6: 84 percent / KH, Bu₄NI / 1,2-dimethoxy-ethane / 0 °C

7: 68 percent / H₂SO₄

8: 64 percent / NaH / dimethylformamide

9: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, -78 deg C, 2) CH₂Cl₂, -78 to 0 deg C

10: 62 percent / TMSOTf / CH₂Cl₂ / -78 °C

11: 66 percent / TMSOTf / CH₂Cl₂ / -45 °C

With 1H-imidazole; potassium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; iodine; tetra-(n-butyl)ammonium iodide; potassium hydride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)00971-X