methyl (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-(phenylsulfonyl)-1H-indol-3-yl)propaneamido)-3-((tert-butyldiphenylsilyl)oxy) propanoate

Base Information

Chemical Name:methyl (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-(phenylsulfonyl)-1H-indol-3-yl)propaneamido)-3-((tert-butyldiphenylsilyl)oxy) propanoate
CAS No.:1252612-39-7
Molecular Formula:C₄₂H₄₉N₃O₈SSi
Molecular Weight:784.018
Hs Code.:

Synonyms:methyl (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-(phenylsulfonyl)-1H-indol-3-yl)propaneamido)-3-((tert-butyldiphenylsilyl)oxy) propanoate

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Chemical Property of methyl (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-(phenylsulfonyl)-1H-indol-3-yl)propaneamido)-3-((tert-butyldiphenylsilyl)oxy) propanoate

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Technology Process of methyl (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-(phenylsulfonyl)-1H-indol-3-yl)propaneamido)-3-((tert-butyldiphenylsilyl)oxy) propanoate

There total 1 articles about methyl (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-(phenylsulfonyl)-1H-indol-3-yl)propaneamido)-3-((tert-butyldiphenylsilyl)oxy) propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1020064-54-3
(-)-(S)-2-(tert-butoxycarbonylamino)-3-(1-phenylsulfonyl-1H-indol-3-yl)propanoic acid

: 140408-49-7
(S)-methyl 2-amino-3-((tert-butyldiphenylsilyl)oxy)propanoate

: 1252612-39-7
methyl (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-(phenylsulfonyl)-1H-indol-3-yl)propaneamido)-3-((tert-butyldiphenylsilyl)oxy) propanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 23 ℃; for 18.0833h; Molecular sieve; Inert atmosphere;
DOI:10.1021/ja106869s

Reference yield: 93.0%

: 1252612-39-7
methyl (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-(phenylsulfonyl)-1H-indol-3-yl)propaneamido)-3-((tert-butyldiphenylsilyl)oxy) propanoate

: 1252612-07-9
(3S,6S)-3-(((tert-butyldiphenylsilyl)oxy)methyl)-6-((1-(phenylsulfonyl)-1H-indol-3-yl)methyl)piperazine-2,5-dione

Guidance literature:: methyl (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-(phenylsulfonyl)-1H-indol-3-yl)propaneamido)-3-((tert-butyldiphenylsilyl)oxy) propanoate; With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 1.5h; Inert atmosphere;

With morpholine; In tert-butyl alcohol; at 30 ℃; for 16h; stereoselective reaction; Cooling with ice; Inert atmosphere;
DOI:10.1021/ja106869s