(-)-(S)-2-(tert-butoxycarbonylamino)-3-(1-phenylsulfonyl-1H-indol-3-yl)propanoic acid

Base Information

Chemical Name:(-)-(S)-2-(tert-butoxycarbonylamino)-3-(1-phenylsulfonyl-1H-indol-3-yl)propanoic acid
CAS No.:1020064-54-3
Molecular Formula:C₂₂H₂₄N₂O₆S
Molecular Weight:444.508
Hs Code.:

Synonyms:(-)-(S)-2-(tert-butoxycarbonylamino)-3-(1-phenylsulfonyl-1H-indol-3-yl)propanoic acid

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Chemical Property of (-)-(S)-2-(tert-butoxycarbonylamino)-3-(1-phenylsulfonyl-1H-indol-3-yl)propanoic acid

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Technology Process of (-)-(S)-2-(tert-butoxycarbonylamino)-3-(1-phenylsulfonyl-1H-indol-3-yl)propanoic acid

There total 1 articles about (-)-(S)-2-(tert-butoxycarbonylamino)-3-(1-phenylsulfonyl-1H-indol-3-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 13139-14-5
Boc-Trp-OH

: 98-09-9
benzenesulfonyl chloride

: 1020064-54-3
(-)-(S)-2-(tert-butoxycarbonylamino)-3-(1-phenylsulfonyl-1H-indol-3-yl)propanoic acid

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1002/anie.200704960

Reference yield: 99.0%

: 1020064-54-3
(-)-(S)-2-(tert-butoxycarbonylamino)-3-(1-phenylsulfonyl-1H-indol-3-yl)propanoic acid

: 140408-49-7
(S)-methyl 2-amino-3-((tert-butyldiphenylsilyl)oxy)propanoate

: 1252612-39-7
methyl (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-(phenylsulfonyl)-1H-indol-3-yl)propaneamido)-3-((tert-butyldiphenylsilyl)oxy) propanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 23 ℃; for 18.0833h; Molecular sieve; Inert atmosphere;
DOI:10.1021/ja106869s

Reference yield: 94.0%

: 1020064-54-3
(-)-(S)-2-(tert-butoxycarbonylamino)-3-(1-phenylsulfonyl-1H-indol-3-yl)propanoic acid

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 1020064-55-4
methyl (S)-[(S)-2-(tert-butoxycarbonylamino)-3-(1-phenylsulfonyl-1H-indol-3-yl)propanamido]-3-phenylpropanoate

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 23 ℃; for 23h;
DOI:10.1002/anie.200704960