methyl 3-(4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-3-yl)propanoate

Base Information

Chemical Name:methyl 3-(4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-3-yl)propanoate
CAS No.:1415333-83-3
Molecular Formula:C₂₁H₂₄N₂O₅
Molecular Weight:384.432
Hs Code.:

Synonyms:methyl 3-(4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-3-yl)propanoate

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Chemical Property of methyl 3-(4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-3-yl)propanoate

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Technology Process of methyl 3-(4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-3-yl)propanoate

There total 5 articles about methyl 3-(4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1415333-63-9
methyl 3-(4-((4-methoxyphenyl)(methyl)carbamoyloxy)-1H-indol-3-yl)propanoate

: 1415333-83-3
methyl 3-(4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-3-yl)propanoate

Guidance literature:: With sodium tetrahydroborate; In trifluoroacetic acid; at 20 ℃; Cooling with ice;
DOI:10.1021/jm301411g

Reference yield: 76.0%

: 1415333-83-3
methyl 3-(4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-3-yl)propanoate

Guidance literature:: With sodium tetrahydroborate; trifluoroacetic acid; at 20 ℃; Cooling with ice;

Reference yield:

: 2380-94-1
1H-indol-4-ol

: 1415333-83-3
methyl 3-(4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-3-yl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; dmap / dichloromethane / 20 °C

2: trichlorophosphate / 0.75 h / 10 - 35 °C / Inert atmosphere

3: pyridine; piperidine / Reflux

4: palladium 10% on activated carbon; ammonium formate / ethanol / 1 h / Reflux

5: sodium tetrahydroborate / trifluoroacetic acid / 20 °C / Cooling with ice

With piperidine; pyridine; dmap; sodium tetrahydroborate; palladium 10% on activated carbon; ammonium formate; triethylamine; trichlorophosphate; In ethanol; dichloromethane; trifluoroacetic acid; 2: |Vilsmeier-Haack Formylation / 3: |Knoevenagel Condensation;
DOI:10.1021/jm301411g