3-(3-methoxy-3-oxopropyl)-4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-1-ium hydrochloride

Base Information

Chemical Name:3-(3-methoxy-3-oxopropyl)-4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-1-ium hydrochloride
CAS No.:1415334-00-7
Molecular Formula:C₂₁H₂₄N₂O₅*ClH
Molecular Weight:420.893
Hs Code.:

Synonyms:3-(3-methoxy-3-oxopropyl)-4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-1-ium hydrochloride

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Chemical Property of 3-(3-methoxy-3-oxopropyl)-4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-1-ium hydrochloride

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Technology Process of 3-(3-methoxy-3-oxopropyl)-4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-1-ium hydrochloride

There total 4 articles about 3-(3-methoxy-3-oxopropyl)-4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-1-ium hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1415333-83-3
methyl 3-(4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-3-yl)propanoate

: 1415334-00-7
3-(3-methoxy-3-oxopropyl)-4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-1-ium hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether;
DOI:10.1021/jm301411g

Reference yield:

: 2380-94-1
1H-indol-4-ol

: 1415334-00-7
3-(3-methoxy-3-oxopropyl)-4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-1-ium hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; dmap / dichloromethane / 20 °C

2: trichlorophosphate / 0.75 h / 10 - 35 °C / Inert atmosphere

3: pyridine; piperidine / Reflux

4: palladium 10% on activated carbon; ammonium formate / ethanol / 1 h / Reflux

5: sodium tetrahydroborate / trifluoroacetic acid / 20 °C / Cooling with ice

6: hydrogenchloride / diethyl ether

With piperidine; pyridine; hydrogenchloride; dmap; sodium tetrahydroborate; palladium 10% on activated carbon; ammonium formate; triethylamine; trichlorophosphate; In diethyl ether; ethanol; dichloromethane; trifluoroacetic acid; 2: |Vilsmeier-Haack Formylation / 3: |Knoevenagel Condensation;
DOI:10.1021/jm301411g

Reference yield:

: 1415333-19-5
1H-indol-4-yl (4-methoxyphenyl)(methyl)carbamate

: 1415334-00-7
3-(3-methoxy-3-oxopropyl)-4-(((4-methoxyphenyl)(methyl)carbamoyl)oxy)indolin-1-ium hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / 0.75 h / 10 - 35 °C / Inert atmosphere

2: pyridine; piperidine / Reflux

3: palladium 10% on activated carbon; ammonium formate / ethanol / 1 h / Reflux

4: sodium tetrahydroborate / trifluoroacetic acid / 20 °C / Cooling with ice

5: hydrogenchloride / diethyl ether

With piperidine; pyridine; hydrogenchloride; sodium tetrahydroborate; palladium 10% on activated carbon; ammonium formate; trichlorophosphate; In diethyl ether; ethanol; trifluoroacetic acid; 1: |Vilsmeier-Haack Formylation / 2: |Knoevenagel Condensation;
DOI:10.1021/jm301411g