(RS,SR)-1,2-bis[{[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl]-4-cyclohexene

Base Information

Chemical Name:(RS,SR)-1,2-bis[{[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl]-4-cyclohexene
CAS No.:116503-81-2
Molecular Formula:C₄₀H₅₀O₂Si₂
Molecular Weight:619.007
Hs Code.:

Synonyms:(RS,SR)-1,2-bis[{[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl]-4-cyclohexene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (RS,SR)-1,2-bis[{[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl]-4-cyclohexene

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Technology Process of (RS,SR)-1,2-bis[{[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl]-4-cyclohexene

There total 2 articles about (RS,SR)-1,2-bis[{[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl]-4-cyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 439919-46-7
cis-1,6-dihydroxymethyl-3-cyclohexene

: 58479-61-1
tert-butylchlorodiphenylsilane

: 116503-81-2
(RS,SR)-1,2-bis[{[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl]-4-cyclohexene

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 20h; Ambient temperature;
DOI:10.1016/S0040-4020(97)10201-0

Reference yield:

: 935-79-5
cis-1,2,3,6-tetrahydrophthalic anhydride

: 116503-81-2
(RS,SR)-1,2-bis[{[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl]-4-cyclohexene

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / LiAlH₄ / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) room temperature, 30 min

2: 89 percent / imidazole / dimethylformamide / 20 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)10201-0

Reference yield:

: 116503-81-2
(RS,SR)-1,2-bis[{[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl]-4-cyclohexene

: 116503-89-0
(RS,SR)-1,2-bis<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>cyclodeca-4,8-diyn-6-ene

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) O₃, 2.) (MeO)3P / 1.) EtOAc-MeOH 1:1, -78 deg C, 2.) from -78 deg C to 25 deg C, 10 h

2: PPh₃ / CH₂Cl₂ / 8 h / 0 - 25 °C

3: 74 percent / n-BuLi / tetrahydrofuran / 1.25 h / -78 - 0 °C

4: 97 percent / DIBAL / CH₂Cl₂ / 6.5 h / -78 °C

5: P(oct)3, CBr₄ / diethyl ether / 1 h / 0 °C

6: 58 percent / Na₂S*9H₂O / ethanol; H₂O / 1.5 h / 78 °C

7: 90 percent / mCPBA / CH₂Cl₂ / 0.5 h / -30 °C

8: 79 percent / SO₂Cl₂/pyridine / CH₂Cl₂ / 0.17 h / -78 °C

9: 99 percent / mCPBA / CH₂Cl₂ / 18 h

10: 20 percent / MeLi / diethyl ether / 0.25 h / -78 °C

With pyridine; sodium sulfide; n-butyllithium; sulfuryl dichloride; carbon tetrabromide; TOP; methyllithium; diisobutylaluminium hydride; ozone; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; phosphorous acid trimethyl ester; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1021/ja00229a068