4-{16'-[3,5-di(4-methoxybenzylamino)-2,4,6-triazinylamino]ethyloxy-16'-oxohexadecanyl}-1-{6'-[(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)amino]-6'-oxohexyl}-1,2,3-triazole

Base Information

Chemical Name:4-{16'-[3,5-di(4-methoxybenzylamino)-2,4,6-triazinylamino]ethyloxy-16'-oxohexadecanyl}-1-{6'-[(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)amino]-6'-oxohexyl}-1,2,3-triazole
CAS No.:1391054-48-0
Molecular Formula:C₆₅H₈₈N₁₀O₁₀
Molecular Weight:1169.47
Hs Code.:

4-{16'-[3,5-di(4-methoxybenzylamino)-2,4,6-triazinylamino]ethyloxy-16'-oxohexadecanyl}-1-{6'-[(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)amino]-6'-oxohexyl}-1,2,3-triazole

Synonyms:4-{16'-[3,5-di(4-methoxybenzylamino)-2,4,6-triazinylamino]ethyloxy-16'-oxohexadecanyl}-1-{6'-[(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)amino]-6'-oxohexyl}-1,2,3-triazole

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Chemical Property of 4-{16'-[3,5-di(4-methoxybenzylamino)-2,4,6-triazinylamino]ethyloxy-16'-oxohexadecanyl}-1-{6'-[(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)amino]-6'-oxohexyl}-1,2,3-triazole

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Technology Process of 4-{16'-[3,5-di(4-methoxybenzylamino)-2,4,6-triazinylamino]ethyloxy-16'-oxohexadecanyl}-1-{6'-[(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)amino]-6'-oxohexyl}-1,2,3-triazole

There total 6 articles about 4-{16'-[3,5-di(4-methoxybenzylamino)-2,4,6-triazinylamino]ethyloxy-16'-oxohexadecanyl}-1-{6'-[(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)amino]-6'-oxohexyl}-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1391054-18-4
N-(6-azidocaproyl)deacetylcolchicine

: 1391054-35-5
2,4-di(4'-methoxybenzylamino)-6-[2'-(17-octadecynoyloxy)ethylamino]-1,3,5-triazine

: 1391054-48-0
4-{16'-[3,5-di(4-methoxybenzylamino)-2,4,6-triazinylamino]ethyloxy-16'-oxohexadecanyl}-1-{6'-[(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)amino]-6'-oxohexyl}-1,2,3-triazole

Guidance literature:: With magnesium ascorbate; copper(II) sulfate; In tetrahydrofuran; water; at 20 ℃; for 24h;
DOI:10.1016/j.bmc.2012.05.072

Reference yield:

: 79598-53-1
6-azidohexanoic acid

: 1391054-48-0
4-{16'-[3,5-di(4-methoxybenzylamino)-2,4,6-triazinylamino]ethyloxy-16'-oxohexadecanyl}-1-{6'-[(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)amino]-6'-oxohexyl}-1,2,3-triazole

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2: magnesium ascorbate; copper(II) sulfate / tetrahydrofuran; water / 24 h / 20 °C

With dmap; magnesium ascorbate; copper(II) sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water; 1: Steglich amidation;
DOI:10.1016/j.bmc.2012.05.072

Reference yield:

: 3476-50-4
deacetylcolchicine

: 1391054-48-0
4-{16'-[3,5-di(4-methoxybenzylamino)-2,4,6-triazinylamino]ethyloxy-16'-oxohexadecanyl}-1-{6'-[(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)amino]-6'-oxohexyl}-1,2,3-triazole

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2: magnesium ascorbate; copper(II) sulfate / tetrahydrofuran; water / 24 h / 20 °C

With dmap; magnesium ascorbate; copper(II) sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water; 1: Steglich amidation;
DOI:10.1016/j.bmc.2012.05.072