1-[3'-Deoxy-6'-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil

Base Information

• Chemical Name: 1-[3'-Deoxy-6'-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil
• CAS No.: 175355-17-6
• Molecular Formula: C₃₁H₃₂N₂O₈
• Molecular Weight: 560.604
• Mol file: 175355-17-6.mol

Synonyms:1-[3'-Deoxy-6'-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil

Chemical Property of 1-[3'-Deoxy-6'-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[3'-Deoxy-6'-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil

There total 1 articles about 1-[3'-Deoxy-6'-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 1-(3'-deoxy-β-D-psicofuranosyl)uracil (55697-37-5) → 1-[3'-Deoxy-6'-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil (175355-17-6)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 25h;

DOI:10.1039/b004774k

Reference yield: 85.0%

benzyl bromide (100-39-0) + 1-[3'-Deoxy-6'-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil (175355-17-6) → 1-[1',4'-di-O-benzyl-3'-deoxy-6'-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil (361344-44-7)

Guidance literature:

benzyl bromide; 1-[3'-Deoxy-6'-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 8h;

benzyl bromide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 15h; Further stages.;

DOI:10.1021/jo015664l

Reference yield: 76.5%

p-toluenesulfonyl chloride (98-59-9) + 1-[3'-Deoxy-6'-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil (175355-17-6) → 1-[3'-Deoxy-6'-O-(4,4'-dimethoxytrityl)-1'-O-(p-tolylsulfonyl)-β-D-psicofuranosyl]uracil (307306-29-2)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1039/b004774k

upstream raw materials:

4,4'-dimethoxytrityl chloride

1-(3'-deoxy-β-D-psicofuranosyl)uracil

Downstream raw materials:

1-[3'-Deoxy-6'-O-(4,4'-dimethoxytrityl)-1'-O-(p-tolylsulfonyl)-β-D-psicofuranosyl]uracil

1-[1',4'-di-O-benzyl-3'-deoxy-6'-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil

(1S,5S,6S)-6-benzyloxy-5-hydroxymethyl-1-(uracil-1-yl)-3,8-dioxabicyclo[3.2.1]octane

(1S,5R,6S)-6-benzyloxy-5-methanesulfonyloxymethyl-1-(uracil-1-yl)-3,8-dioxabicyclo[3.2.1]octane